Calmodulin in ischemic neurotoxicity of rat hippocampus in vitro

Xiaofeng Sun, Cheolsu Shin, Anthony J. Windebank

Research output: Contribution to journalArticle

17 Scopus citations

Abstract

To determine whether calmodulin plays a role in neurodegeneration after ischemia, effects of the selective calmodulin inhibitors calmidazolium and W7 were studied in organotypic cultures of rat hippocampus. Protection of pyramidal cells in the CA1 region of the hippocampus by calmidazolium and W7 against hypoxia/hypoglycemia suggests that activation of intracellular calmodulin plays a significant role in ischemic neuronal injury. Both ryanodine and TMB-8, inhibitors of intracellular Ca2+ release, failed to prevent ischemic neuronal injury. These results indicate that calmodulin, a major intracellular Ca2+ binding protein, plays a significant role in experimental ischemia-induced hippocampal neuronal injury in vitro.

Original languageEnglish (US)
Pages (from-to)415-418
Number of pages4
JournalNeuroReport
Volume8
Issue number2
DOIs
StatePublished - 1997

Keywords

  • Calmodulin
  • Hippocampus
  • Ischemia
  • Neuronal degeneration
  • Organotypic culture
  • Rat

ASJC Scopus subject areas

  • Neuroscience(all)

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