Calmodulin in ischemic neurotoxicity of rat hippocampus in vitro

Xiaofeng Sun, Cheolsu Shin, Anthony John Windebank

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

To determine whether calmodulin plays a role in neurodegeneration after ischemia, effects of the selective calmodulin inhibitors calmidazolium and W7 were studied in organotypic cultures of rat hippocampus. Protection of pyramidal cells in the CA1 region of the hippocampus by calmidazolium and W7 against hypoxia/hypoglycemia suggests that activation of intracellular calmodulin plays a significant role in ischemic neuronal injury. Both ryanodine and TMB-8, inhibitors of intracellular Ca 2+ release, failed to prevent ischemic neuronal injury. These results indicate that calmodulin, a major intracellular Ca 2+ binding protein, plays a significant role in experimental ischemia-induced hippocampal neuronal injury in vitro.

Original languageEnglish (US)
Pages (from-to)415-418
Number of pages4
JournalNeuroReport
Volume8
Issue number2
StatePublished - 1997

Fingerprint

Calmodulin
calmidazolium
Hippocampus
Wounds and Injuries
Ischemia
Ryanodine
Pyramidal Cells
Hypoglycemia
In Vitro Techniques
W 7

Keywords

  • Calmodulin
  • Hippocampus
  • Ischemia
  • Neuronal degeneration
  • Organotypic culture
  • Rat

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Calmodulin in ischemic neurotoxicity of rat hippocampus in vitro. / Sun, Xiaofeng; Shin, Cheolsu; Windebank, Anthony John.

In: NeuroReport, Vol. 8, No. 2, 1997, p. 415-418.

Research output: Contribution to journalArticle

Sun, Xiaofeng ; Shin, Cheolsu ; Windebank, Anthony John. / Calmodulin in ischemic neurotoxicity of rat hippocampus in vitro. In: NeuroReport. 1997 ; Vol. 8, No. 2. pp. 415-418.
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