Call to Action: SARS-CoV-2 and CerebrovAscular DisordErs (CASCADE)

Shahram Abootalebi; Benjamin M. Aertker; Mohammad Sobhan Andalibi; Negar Asdaghi; Ozlem Aykac; M. Reza Azarpazhooh; M. Cecilia Bahit; Kristian Barlinn; Hamidon Basri; Reza Bavarsad Shahripour; Anna Bersano; Jose Biller; Afshin Borhani-Haghighi; Robert D. Brown; Bruce CV Campbell; Salvador Cruz-Flores; Deidre Anne De Silva; Mario Di Napoli; Afshin A. Divani; Randall C. Edgell; Johanna T. Fifi; Abdoreza Ghoreishi; Teruyuki Hirano; Keun Sik Hong; Chung Y. Hsu; Josephine F. Huang; Manabu Inoue; Amanda L. Jagolino; Moira Kapral; Hoo Fan Kee; Zafer Keser; Rakesh Khatri; Masatoshi Koga; Jerzy Krupinski; David S. Liebeskind; Liping Liu; Henry Ma; Alberto Maud; Louise D. McCullough; Dawn Matherne Meyer; Victoria Mifsud; Negar Morovatdar; Yongchai Nilanont; Thomas J. Oxley; Atilla Özcan Özdemir; Jeyaraj Pandian; Leonardo Pantoni; Nikolaos I.H. Papamitsakis; Adrian Parry-Jones; Thanh Phan; Gustavo Rodriguez; Jose G. Romano; Ziad Sabaa-Ayoun; Hamidreza Saber; Payam Sasannezhad; Jeffrey L. Saver; Eugene Scharf; Ashfaq Shuaib; Brian Silver; Shaloo Singhal; Craig J. Smith; Saverio Stranges; P. N. Sylaja; Michel Torbey; Kazunori Toyoda; Georgios Tsivgoulis; Mohammad Wasay; Nawaf Yassi; Takeshi Yoshimoto; Babak Zamani; Ramin Zand

doi:10.1016/j.jstrokecerebrovasdis.2020.104938

Call to Action: SARS-CoV-2 and CerebrovAscular DisordErs (CASCADE)

Shahram Abootalebi, Benjamin M. Aertker, Mohammad Sobhan Andalibi, Negar Asdaghi, Ozlem Aykac, M. Reza Azarpazhooh, M. Cecilia Bahit, Kristian Barlinn, Hamidon Basri, Reza Bavarsad Shahripour, Anna Bersano, Jose Biller, Afshin Borhani-Haghighi, Robert D. Brown, Bruce CV Campbell, Salvador Cruz-Flores, Deidre Anne De Silva, Mario Di Napoli, Afshin A. Divani, Randall C. EdgellJohanna T. Fifi, Abdoreza Ghoreishi, Teruyuki Hirano, Keun Sik Hong, Chung Y. Hsu, Josephine F. Huang, Manabu Inoue, Amanda L. Jagolino, Moira Kapral, Hoo Fan Kee, Zafer Keser, Rakesh Khatri, Masatoshi Koga, Jerzy Krupinski, David S. Liebeskind, Liping Liu, Henry Ma, Alberto Maud, Louise D. McCullough, Dawn Matherne Meyer, Victoria Mifsud, Negar Morovatdar, Yongchai Nilanont, Thomas J. Oxley, Atilla Özcan Özdemir, Jeyaraj Pandian, Leonardo Pantoni, Nikolaos I.H. Papamitsakis, Adrian Parry-Jones, Thanh Phan, Gustavo Rodriguez, Jose G. Romano, Ziad Sabaa-Ayoun, Hamidreza Saber, Payam Sasannezhad, Jeffrey L. Saver, Eugene Scharf, Ashfaq Shuaib, Brian Silver, Shaloo Singhal, Craig J. Smith, Saverio Stranges, P. N. Sylaja, Michel Torbey, Kazunori Toyoda, Georgios Tsivgoulis, Mohammad Wasay, Nawaf Yassi, Takeshi Yoshimoto, Babak Zamani, Ramin Zand

Neurology

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

Background and purpose: The novel severe acute respiratory syndrome coronavirus 2 (SARS-Cov-2), now named coronavirus disease 2019 (COVID-19), may change the risk of stroke through an enhanced systemic inflammatory response, hypercoagulable state, and endothelial damage in the cerebrovascular system. Moreover, due to the current pandemic, some countries have prioritized health resources towards COVID-19 management, making it more challenging to appropriately care for other potentially disabling and fatal diseases such as stroke. The aim of this study is to identify and describe changes in stroke epidemiological trends before, during, and after the COVID-19 pandemic. Methods: This is an international, multicenter, hospital-based study on stroke incidence and outcomes during the COVID-19 pandemic. We will describe patterns in stroke management, stroke hospitalization rate, and stroke severity, subtype (ischemic/hemorrhagic), and outcomes (including in-hospital mortality) in 2020 during COVID-19 pandemic, comparing them with the corresponding data from 2018 and 2019, and subsequently 2021. We will also use an interrupted time series (ITS) analysis to assess the change in stroke hospitalization rates before, during, and after COVID-19, in each participating center. Conclusion: The proposed study will potentially enable us to better understand the changes in stroke care protocols, differential hospitalization rate, and severity of stroke, as it pertains to the COVID-19 pandemic. Ultimately, this will help guide clinical-based policies surrounding COVID-19 and other similar global pandemics to ensure that management of cerebrovascular comorbidity is appropriately prioritized during the global crisis. It will also guide public health guidelines for at-risk populations to reduce risks of complications from such comorbidities.

Original language	English (US)
Article number	104938
Journal	Journal of Stroke and Cerebrovascular Diseases
Volume	29
Issue number	9
DOIs	https://doi.org/10.1016/j.jstrokecerebrovasdis.2020.104938
State	Published - Sep 2020

Keywords

COVID-19
Health policy
Incidence
Mortality
National crisis
Pandemic
SARS-CoV-2
Stroke

ASJC Scopus subject areas

Surgery
Rehabilitation
Clinical Neurology
Cardiology and Cardiovascular Medicine

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10.1016/j.jstrokecerebrovasdis.2020.104938

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Abootalebi, S., Aertker, B. M., Andalibi, M. S., Asdaghi, N., Aykac, O., Azarpazhooh, M. R., Bahit, M. C., Barlinn, K., Basri, H., Shahripour, R. B., Bersano, A., Biller, J., Borhani-Haghighi, A., Brown, R. D., Campbell, B. CV., Cruz-Flores, S., De Silva, D. A., Napoli, M. D., Divani, A. A., ... Zand, R. (2020). Call to Action: SARS-CoV-2 and CerebrovAscular DisordErs (CASCADE). Journal of Stroke and Cerebrovascular Diseases, 29(9), Article 104938. https://doi.org/10.1016/j.jstrokecerebrovasdis.2020.104938

Abootalebi, S, Aertker, BM, Andalibi, MS, Asdaghi, N, Aykac, O, Azarpazhooh, MR, Bahit, MC, Barlinn, K, Basri, H, Shahripour, RB, Bersano, A, Biller, J, Borhani-Haghighi, A, Brown, RD, Campbell, BCV, Cruz-Flores, S, De Silva, DA, Napoli, MD, Divani, AA, Edgell, RC, Fifi, JT, Ghoreishi, A, Hirano, T, Hong, KS, Hsu, CY, Huang, JF, Inoue, M, Jagolino, AL, Kapral, M, Kee, HF, Keser, Z, Khatri, R, Koga, M, Krupinski, J, Liebeskind, DS, Liu, L, Ma, H, Maud, A, McCullough, LD, Meyer, DM, Mifsud, V, Morovatdar, N, Nilanont, Y, Oxley, TJ, Özdemir, AÖ, Pandian, J, Pantoni, L, Papamitsakis, NIH, Parry-Jones, A, Phan, T, Rodriguez, G, Romano, JG, Sabaa-Ayoun, Z, Saber, H, Sasannezhad, P, Saver, JL, Scharf, E, Shuaib, A, Silver, B, Singhal, S, Smith, CJ, Stranges, S, Sylaja, PN, Torbey, M, Toyoda, K, Tsivgoulis, G, Wasay, M, Yassi, N, Yoshimoto, T, Zamani, B & Zand, R 2020, 'Call to Action: SARS-CoV-2 and CerebrovAscular DisordErs (CASCADE)', Journal of Stroke and Cerebrovascular Diseases, vol. 29, no. 9, 104938. https://doi.org/10.1016/j.jstrokecerebrovasdis.2020.104938

@article{aef9d94153b547b091ecb04d864e0219,

title = "Call to Action: SARS-CoV-2 and CerebrovAscular DisordErs (CASCADE)",

abstract = "Background and purpose: The novel severe acute respiratory syndrome coronavirus 2 (SARS-Cov-2), now named coronavirus disease 2019 (COVID-19), may change the risk of stroke through an enhanced systemic inflammatory response, hypercoagulable state, and endothelial damage in the cerebrovascular system. Moreover, due to the current pandemic, some countries have prioritized health resources towards COVID-19 management, making it more challenging to appropriately care for other potentially disabling and fatal diseases such as stroke. The aim of this study is to identify and describe changes in stroke epidemiological trends before, during, and after the COVID-19 pandemic. Methods: This is an international, multicenter, hospital-based study on stroke incidence and outcomes during the COVID-19 pandemic. We will describe patterns in stroke management, stroke hospitalization rate, and stroke severity, subtype (ischemic/hemorrhagic), and outcomes (including in-hospital mortality) in 2020 during COVID-19 pandemic, comparing them with the corresponding data from 2018 and 2019, and subsequently 2021. We will also use an interrupted time series (ITS) analysis to assess the change in stroke hospitalization rates before, during, and after COVID-19, in each participating center. Conclusion: The proposed study will potentially enable us to better understand the changes in stroke care protocols, differential hospitalization rate, and severity of stroke, as it pertains to the COVID-19 pandemic. Ultimately, this will help guide clinical-based policies surrounding COVID-19 and other similar global pandemics to ensure that management of cerebrovascular comorbidity is appropriately prioritized during the global crisis. It will also guide public health guidelines for at-risk populations to reduce risks of complications from such comorbidities.",

keywords = "COVID-19, Health policy, Incidence, Mortality, National crisis, Pandemic, SARS-CoV-2, Stroke",

author = "Shahram Abootalebi and Aertker, {Benjamin M.} and Andalibi, {Mohammad Sobhan} and Negar Asdaghi and Ozlem Aykac and Azarpazhooh, {M. Reza} and Bahit, {M. Cecilia} and Kristian Barlinn and Hamidon Basri and Shahripour, {Reza Bavarsad} and Anna Bersano and Jose Biller and Afshin Borhani-Haghighi and Brown, {Robert D.} and Campbell, {Bruce CV} and Salvador Cruz-Flores and {De Silva}, {Deidre Anne} and Napoli, {Mario Di} and Divani, {Afshin A.} and Edgell, {Randall C.} and Fifi, {Johanna T.} and Abdoreza Ghoreishi and Teruyuki Hirano and Hong, {Keun Sik} and Hsu, {Chung Y.} and Huang, {Josephine F.} and Manabu Inoue and Jagolino, {Amanda L.} and Moira Kapral and Kee, {Hoo Fan} and Zafer Keser and Rakesh Khatri and Masatoshi Koga and Jerzy Krupinski and Liebeskind, {David S.} and Liping Liu and Henry Ma and Alberto Maud and McCullough, {Louise D.} and Meyer, {Dawn Matherne} and Victoria Mifsud and Negar Morovatdar and Yongchai Nilanont and Oxley, {Thomas J.} and {\"O}zdemir, {Atilla {\"O}zcan} and Jeyaraj Pandian and Leonardo Pantoni and Papamitsakis, {Nikolaos I.H.} and Adrian Parry-Jones and Thanh Phan and Gustavo Rodriguez and Romano, {Jose G.} and Ziad Sabaa-Ayoun and Hamidreza Saber and Payam Sasannezhad and Saver, {Jeffrey L.} and Eugene Scharf and Ashfaq Shuaib and Brian Silver and Shaloo Singhal and Smith, {Craig J.} and Saverio Stranges and Sylaja, {P. N.} and Michel Torbey and Kazunori Toyoda and Georgios Tsivgoulis and Mohammad Wasay and Nawaf Yassi and Takeshi Yoshimoto and Babak Zamani and Ramin Zand",

note = "Publisher Copyright: {\textcopyright} 2020",

year = "2020",

month = sep,

doi = "10.1016/j.jstrokecerebrovasdis.2020.104938",

language = "English (US)",

volume = "29",

journal = "Journal of Stroke and Cerebrovascular Diseases",

issn = "1052-3057",

publisher = "W.B. Saunders Ltd",

number = "9",

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TY - JOUR

T1 - Call to Action

T2 - SARS-CoV-2 and CerebrovAscular DisordErs (CASCADE)

AU - Abootalebi, Shahram

AU - Aertker, Benjamin M.

AU - Andalibi, Mohammad Sobhan

AU - Asdaghi, Negar

AU - Aykac, Ozlem

AU - Azarpazhooh, M. Reza

AU - Bahit, M. Cecilia

AU - Barlinn, Kristian

AU - Basri, Hamidon

AU - Shahripour, Reza Bavarsad

AU - Bersano, Anna

AU - Biller, Jose

AU - Borhani-Haghighi, Afshin

AU - Brown, Robert D.

AU - Campbell, Bruce CV

AU - Cruz-Flores, Salvador

AU - De Silva, Deidre Anne

AU - Napoli, Mario Di

AU - Divani, Afshin A.

AU - Edgell, Randall C.

AU - Fifi, Johanna T.

AU - Ghoreishi, Abdoreza

AU - Hirano, Teruyuki

AU - Hong, Keun Sik

AU - Hsu, Chung Y.

AU - Huang, Josephine F.

AU - Inoue, Manabu

AU - Jagolino, Amanda L.

AU - Kapral, Moira

AU - Kee, Hoo Fan

AU - Keser, Zafer

AU - Khatri, Rakesh

AU - Koga, Masatoshi

AU - Krupinski, Jerzy

AU - Liebeskind, David S.

AU - Liu, Liping

AU - Ma, Henry

AU - Maud, Alberto

AU - McCullough, Louise D.

AU - Meyer, Dawn Matherne

AU - Mifsud, Victoria

AU - Morovatdar, Negar

AU - Nilanont, Yongchai

AU - Oxley, Thomas J.

AU - Özdemir, Atilla Özcan

AU - Pandian, Jeyaraj

AU - Pantoni, Leonardo

AU - Papamitsakis, Nikolaos I.H.

AU - Parry-Jones, Adrian

AU - Phan, Thanh

AU - Rodriguez, Gustavo

AU - Romano, Jose G.

AU - Sabaa-Ayoun, Ziad

AU - Saber, Hamidreza

AU - Sasannezhad, Payam

AU - Saver, Jeffrey L.

AU - Scharf, Eugene

AU - Shuaib, Ashfaq

AU - Silver, Brian

AU - Singhal, Shaloo

AU - Smith, Craig J.

AU - Stranges, Saverio

AU - Sylaja, P. N.

AU - Torbey, Michel

AU - Toyoda, Kazunori

AU - Tsivgoulis, Georgios

AU - Wasay, Mohammad

AU - Yassi, Nawaf

AU - Yoshimoto, Takeshi

AU - Zamani, Babak

AU - Zand, Ramin

PY - 2020/9

Y1 - 2020/9

N2 - Background and purpose: The novel severe acute respiratory syndrome coronavirus 2 (SARS-Cov-2), now named coronavirus disease 2019 (COVID-19), may change the risk of stroke through an enhanced systemic inflammatory response, hypercoagulable state, and endothelial damage in the cerebrovascular system. Moreover, due to the current pandemic, some countries have prioritized health resources towards COVID-19 management, making it more challenging to appropriately care for other potentially disabling and fatal diseases such as stroke. The aim of this study is to identify and describe changes in stroke epidemiological trends before, during, and after the COVID-19 pandemic. Methods: This is an international, multicenter, hospital-based study on stroke incidence and outcomes during the COVID-19 pandemic. We will describe patterns in stroke management, stroke hospitalization rate, and stroke severity, subtype (ischemic/hemorrhagic), and outcomes (including in-hospital mortality) in 2020 during COVID-19 pandemic, comparing them with the corresponding data from 2018 and 2019, and subsequently 2021. We will also use an interrupted time series (ITS) analysis to assess the change in stroke hospitalization rates before, during, and after COVID-19, in each participating center. Conclusion: The proposed study will potentially enable us to better understand the changes in stroke care protocols, differential hospitalization rate, and severity of stroke, as it pertains to the COVID-19 pandemic. Ultimately, this will help guide clinical-based policies surrounding COVID-19 and other similar global pandemics to ensure that management of cerebrovascular comorbidity is appropriately prioritized during the global crisis. It will also guide public health guidelines for at-risk populations to reduce risks of complications from such comorbidities.

AB - Background and purpose: The novel severe acute respiratory syndrome coronavirus 2 (SARS-Cov-2), now named coronavirus disease 2019 (COVID-19), may change the risk of stroke through an enhanced systemic inflammatory response, hypercoagulable state, and endothelial damage in the cerebrovascular system. Moreover, due to the current pandemic, some countries have prioritized health resources towards COVID-19 management, making it more challenging to appropriately care for other potentially disabling and fatal diseases such as stroke. The aim of this study is to identify and describe changes in stroke epidemiological trends before, during, and after the COVID-19 pandemic. Methods: This is an international, multicenter, hospital-based study on stroke incidence and outcomes during the COVID-19 pandemic. We will describe patterns in stroke management, stroke hospitalization rate, and stroke severity, subtype (ischemic/hemorrhagic), and outcomes (including in-hospital mortality) in 2020 during COVID-19 pandemic, comparing them with the corresponding data from 2018 and 2019, and subsequently 2021. We will also use an interrupted time series (ITS) analysis to assess the change in stroke hospitalization rates before, during, and after COVID-19, in each participating center. Conclusion: The proposed study will potentially enable us to better understand the changes in stroke care protocols, differential hospitalization rate, and severity of stroke, as it pertains to the COVID-19 pandemic. Ultimately, this will help guide clinical-based policies surrounding COVID-19 and other similar global pandemics to ensure that management of cerebrovascular comorbidity is appropriately prioritized during the global crisis. It will also guide public health guidelines for at-risk populations to reduce risks of complications from such comorbidities.

KW - COVID-19

KW - Health policy

KW - Incidence

KW - Mortality

KW - National crisis

KW - Pandemic

KW - SARS-CoV-2

KW - Stroke

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DO - 10.1016/j.jstrokecerebrovasdis.2020.104938

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AN - SCOPUS:85086253184

SN - 1052-3057

VL - 29

JO - Journal of Stroke and Cerebrovascular Diseases

JF - Journal of Stroke and Cerebrovascular Diseases

IS - 9

M1 - 104938

ER -

Call to Action: SARS-CoV-2 and CerebrovAscular DisordErs (CASCADE)

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ASJC Scopus subject areas

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