Calculated panel reactive antibody with decimals: A refined metric of access to transplantation for highly sensitized candidates

Evan P. Kransdorf, Marcelo J. Pando

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

The use of the calculated panel reactive antibody (CPRA) value and the implementation of allocation points for sensitized candidates by the United Network for Organ Sharing (UNOS) have improved access to kidney transplantation for highly sensitized candidates (98% CPRA and above). Despite this, a large population of highly sensitized candidates remain awaiting transplantation. To better define this population, we propose the use of two refinements of the standard UNOS CPRA, the CPRA with decimals or CPRAd, and the likelihood of a compatible donor (LCD). These refined metrics of the standard UNOS CPRA will allow transplant programs to describe their patients' access to transplantation with increased granularity and will help in decisions regarding the use of desensitization.

Original languageEnglish (US)
JournalHuman Immunology
DOIs
StateAccepted/In press - Aug 23 2016

Keywords

  • Calculated panel reactive antibody
  • Histocompatibility
  • Sensitization
  • Transplantation

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Fingerprint Dive into the research topics of 'Calculated panel reactive antibody with decimals: A refined metric of access to transplantation for highly sensitized candidates'. Together they form a unique fingerprint.

Cite this