Calculated panel reactive antibody with decimals: A refined metric of access to transplantation for highly sensitized candidates

Evan P. Kransdorf; Marcelo J. Pando

doi:10.1016/j.humimm.2016.12.009

Calculated panel reactive antibody with decimals: A refined metric of access to transplantation for highly sensitized candidates

Evan P. Kransdorf, Marcelo J. Pando

Laboratory Medicine and Pathology

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

The use of the calculated panel reactive antibody (CPRA) value and the implementation of allocation points for sensitized candidates by the United Network for Organ Sharing (UNOS) have improved access to kidney transplantation for highly sensitized candidates (98% CPRA and above). Despite this, a large population of highly sensitized candidates remain awaiting transplantation. To better define this population, we propose the use of two refinements of the standard UNOS CPRA, the CPRA with decimals or CPRAd, and the likelihood of a compatible donor (LCD). These refined metrics of the standard UNOS CPRA will allow transplant programs to describe their patients’ access to transplantation with increased granularity and will help in decisions regarding the use of desensitization.

Original language	English (US)
Pages (from-to)	252-256
Number of pages	5
Journal	Human Immunology
Volume	78
Issue number	3
DOIs	https://doi.org/10.1016/j.humimm.2016.12.009
State	Published - Mar 1 2017

Keywords

Calculated panel reactive antibody
Histocompatibility
Sensitization
Transplantation

ASJC Scopus subject areas

Immunology and Allergy
Immunology

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10.1016/j.humimm.2016.12.009

Cite this

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title = "Calculated panel reactive antibody with decimals: A refined metric of access to transplantation for highly sensitized candidates",

abstract = "The use of the calculated panel reactive antibody (CPRA) value and the implementation of allocation points for sensitized candidates by the United Network for Organ Sharing (UNOS) have improved access to kidney transplantation for highly sensitized candidates (98% CPRA and above). Despite this, a large population of highly sensitized candidates remain awaiting transplantation. To better define this population, we propose the use of two refinements of the standard UNOS CPRA, the CPRA with decimals or CPRAd, and the likelihood of a compatible donor (LCD). These refined metrics of the standard UNOS CPRA will allow transplant programs to describe their patients{\textquoteright} access to transplantation with increased granularity and will help in decisions regarding the use of desensitization.",

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AB - The use of the calculated panel reactive antibody (CPRA) value and the implementation of allocation points for sensitized candidates by the United Network for Organ Sharing (UNOS) have improved access to kidney transplantation for highly sensitized candidates (98% CPRA and above). Despite this, a large population of highly sensitized candidates remain awaiting transplantation. To better define this population, we propose the use of two refinements of the standard UNOS CPRA, the CPRA with decimals or CPRAd, and the likelihood of a compatible donor (LCD). These refined metrics of the standard UNOS CPRA will allow transplant programs to describe their patients’ access to transplantation with increased granularity and will help in decisions regarding the use of desensitization.

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Calculated panel reactive antibody with decimals: A refined metric of access to transplantation for highly sensitized candidates

Abstract

Keywords

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