Calcium transport in epithelial cells of the intestine and kidney

Research output: Contribution to journalArticle

39 Citations (Scopus)

Abstract

The central role of 1α,25-dihydroxyvitamin D3 in the regulation of calcium balance is well established. By increasing the absorption of calcium in the intestine and the reabsorption of filtered calcium in the kidney tubule, the hormone maintains an appropriate calcium balance. The cellular mechanisms that underlie the increase in calcium transport in epithelial cells in response to 1α,25-dihydroxyvitamin D3 are beginning to be defined. These events include an increase in the movement of calcium across the apical membrane of the cell, an increase in the movement of calcium across the cell, and an increase in the extrusion of calcium at the basolateral portion of the cell. In this Prospects article, I will discuss the nature of the various processes and proteins involved in transcellular calcium movement, and I will attempt to highlight various future areas of research.

Original languageEnglish (US)
Pages (from-to)392-398
Number of pages7
JournalJournal of Cellular Biochemistry
Volume57
Issue number3
DOIs
StatePublished - 1995

Fingerprint

Intestines
Epithelial Cells
Calcium
Kidney
Calcitriol
Kidney Tubules
Extrusion
Cell Membrane
Hormones
Membranes
Research
Proteins

Keywords

  • 1α,25-dihydroxyvitamin D
  • calbindin
  • calcium pump
  • calcium transport
  • vitamin D-receptor

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology

Cite this

Calcium transport in epithelial cells of the intestine and kidney. / Kumar, Rajiv.

In: Journal of Cellular Biochemistry, Vol. 57, No. 3, 1995, p. 392-398.

Research output: Contribution to journalArticle

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