Abstract
The central role of 1α,25-dihydroxyvitamin D3 in the regulation of calcium balance is well established. By increasing the absorption of calcium in the intestine and the reabsorption of filtered calcium in the kidney tubule, the hormone maintains an appropriate calcium balance. The cellular mechanisms that underlie the increase in calcium transport in epithelial cells in response to 1α,25-dihydroxyvitamin D3 are beginning to be defined. These events include an increase in the movement of calcium across the apical membrane of the cell, an increase in the movement of calcium across the cell, and an increase in the extrusion of calcium at the basolateral portion of the cell. In this Prospects article, I will discuss the nature of the various processes and proteins involved in transcellular calcium movement, and I will attempt to highlight various future areas of research.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 392-398 |
| Number of pages | 7 |
| Journal | Journal of Cellular Biochemistry |
| Volume | 57 |
| Issue number | 3 |
| DOIs | |
| State | Published - 1995 |
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Keywords
- 1α,25-dihydroxyvitamin D
- calbindin
- calcium pump
- calcium transport
- vitamin D-receptor
ASJC Scopus subject areas
- Biochemistry
- Cell Biology
Cite this
Calcium transport in epithelial cells of the intestine and kidney. / Kumar, Rajiv.
In: Journal of Cellular Biochemistry, Vol. 57, No. 3, 1995, p. 392-398.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Calcium transport in epithelial cells of the intestine and kidney
AU - Kumar, Rajiv
PY - 1995
Y1 - 1995
N2 - The central role of 1α,25-dihydroxyvitamin D3 in the regulation of calcium balance is well established. By increasing the absorption of calcium in the intestine and the reabsorption of filtered calcium in the kidney tubule, the hormone maintains an appropriate calcium balance. The cellular mechanisms that underlie the increase in calcium transport in epithelial cells in response to 1α,25-dihydroxyvitamin D3 are beginning to be defined. These events include an increase in the movement of calcium across the apical membrane of the cell, an increase in the movement of calcium across the cell, and an increase in the extrusion of calcium at the basolateral portion of the cell. In this Prospects article, I will discuss the nature of the various processes and proteins involved in transcellular calcium movement, and I will attempt to highlight various future areas of research.
AB - The central role of 1α,25-dihydroxyvitamin D3 in the regulation of calcium balance is well established. By increasing the absorption of calcium in the intestine and the reabsorption of filtered calcium in the kidney tubule, the hormone maintains an appropriate calcium balance. The cellular mechanisms that underlie the increase in calcium transport in epithelial cells in response to 1α,25-dihydroxyvitamin D3 are beginning to be defined. These events include an increase in the movement of calcium across the apical membrane of the cell, an increase in the movement of calcium across the cell, and an increase in the extrusion of calcium at the basolateral portion of the cell. In this Prospects article, I will discuss the nature of the various processes and proteins involved in transcellular calcium movement, and I will attempt to highlight various future areas of research.
KW - 1α,25-dihydroxyvitamin D
KW - calbindin
KW - calcium pump
KW - calcium transport
KW - vitamin D-receptor
UR - http://www.scopus.com/inward/record.url?scp=0028902030&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0028902030&partnerID=8YFLogxK
U2 - 10.1002/jcb.240570304
DO - 10.1002/jcb.240570304
M3 - Article
C2 - 7768975
AN - SCOPUS:0028902030
VL - 57
SP - 392
EP - 398
JO - Journal of Cellular Biochemistry
JF - Journal of Cellular Biochemistry
SN - 0730-2312
IS - 3
ER -