Calcium signalling in T cells stimulated by a cyclophilin B-binding protein

Richard J. Bram, Gerald R. Crabtreet

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131 Scopus citations

Abstract

INSULIN-DEPENDENT diabetes mellitus (IDDM) is a T-cell-mediated autoimmune disease whose onset is believed to be triggered by unknown environmental factors acting on a predisposing genetic background. Islet-infiltrating T (IIT) cells from two IDDM patients, who had died at the onset of the disease from brain swelling as a complication of ketoacidosis, were analysed. The results provided evidence for the involvement of a pancreatic islet cell membrane-bound superantigen1,2 as a diabetes aetiopatho-genetic factor. There was a selective expansion of a T-cell receptor (TCR) variable segment of the β-chain (Vβ7) in these IIT cells in association with unselected Vα-chain segments; extensive junc-tional diversity of the TCR Vβ7 chains; and evidence of positive selection, after exposure to diabetic islet cell membrane preparations, of Vβ7+ T-cell clones among peripheral blood lymphocytes from non-diabetic individuals.

Original languageEnglish (US)
Pages (from-to)355-358
Number of pages4
JournalNature
Volume371
Issue number6495
DOIs
StatePublished - Jan 1 1994

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