TY - JOUR
T1 - Calcium signaling in the ER
T2 - Its role in neuronal plasticity and neurodegenerative disorders
AU - Mattson, Mark P.
AU - LaFerla, Frank M.
AU - Chan, Sic L.
AU - Leissring, Malcolm A.
AU - Shepel, P. Nickolas
AU - Geiger, Jonathan D.
N1 - Funding Information:
The authors’ research is supported by the National Institute on Aging and the Alzheimer’s Association (M.P.M.), the Medical Research Council of Canada (J.D.G. and P.N.S.), and the Alzheimer’s Society of Canada (J.D.G.).
PY - 2000/5/1
Y1 - 2000/5/1
N2 - Endoplasmic reticulum (ER) is a multifaceted organelle that regulates protein synthesis and trafficking, cellular responses to stress, and intracellular Ca2+ levels. In neurons, it is distributed between the cellular compartments that regulate plasticity and survival, which include axons, dendrites, growth cones and synaptic terminals. Intriguing communication networks between ER, mitochondria and plasma membrane are being revealed that provide mechanisms for the precise regulation of temporal and spatial aspects of Ca2+ signaling. Alterations in Ca2+ homeostasis in ER contribute to neuronal apoptosis and excitotoxicity, and are being linked to the pathogenesis of several different neurodegenerative disorders, including Alzheimer's disease and stroke.
AB - Endoplasmic reticulum (ER) is a multifaceted organelle that regulates protein synthesis and trafficking, cellular responses to stress, and intracellular Ca2+ levels. In neurons, it is distributed between the cellular compartments that regulate plasticity and survival, which include axons, dendrites, growth cones and synaptic terminals. Intriguing communication networks between ER, mitochondria and plasma membrane are being revealed that provide mechanisms for the precise regulation of temporal and spatial aspects of Ca2+ signaling. Alterations in Ca2+ homeostasis in ER contribute to neuronal apoptosis and excitotoxicity, and are being linked to the pathogenesis of several different neurodegenerative disorders, including Alzheimer's disease and stroke.
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U2 - 10.1016/S0166-2236(00)01548-4
DO - 10.1016/S0166-2236(00)01548-4
M3 - Review article
C2 - 10782128
AN - SCOPUS:0034194089
SN - 0166-2236
VL - 23
SP - 222
EP - 229
JO - Trends in neurosciences
JF - Trends in neurosciences
IS - 5
ER -