Abstract
The elderly chronic kidney disease (CKD) population is growing. Both aging and CKD can disrupt calcium (Ca2+) homeostasis and cause alterations of multiple Ca2+-regulatory mechanisms, including parathyroid hormone, vitamin D, fibroblast growth factor-23/Klotho, calcium-sensing receptor and Ca2+-phosphate product. These alterations can be deleterious to bone mineral metabolism and soft tissue health, leading to metabolic bone disease and vascular calcification and aging, termed CKD-mineral and bone disorder (MBD). CKD-MBD is associated with morbid clinical outcomes, including fracture, cardiovascular events and all-cause mortality. In this paper, we comprehensively review Ca2+ regulation and bone mineral metabolism, with a special emphasis on elderly CKD patients. We also present the current treatment-guidelines and management options for CKD-MBD.
Original language | English (US) |
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Pages (from-to) | 1913-1936 |
Number of pages | 24 |
Journal | Nutrients |
Volume | 5 |
Issue number | 6 |
DOIs | |
State | Published - May 29 2013 |
Keywords
- Aging
- Calcium homeostasis
- Chronic kidney disease
- Mineral and bone disorder
- Secondary hyperparathyroidism
- Vascular calcification
ASJC Scopus subject areas
- Food Science
- Nutrition and Dietetics