Calcium regulation and bone mineral metabolism in elderly patients with chronic kidney disease

Vickram Tejwani; Qi Qian

doi:10.3390/nu5061913

Calcium regulation and bone mineral metabolism in elderly patients with chronic kidney disease

Vickram Tejwani, Qi Qian

Nephrology and Hypertension

Research output: Contribution to journal › Review article › peer-review

20 Scopus citations

Abstract

The elderly chronic kidney disease (CKD) population is growing. Both aging and CKD can disrupt calcium (Ca²⁺) homeostasis and cause alterations of multiple Ca²⁺-regulatory mechanisms, including parathyroid hormone, vitamin D, fibroblast growth factor-23/Klotho, calcium-sensing receptor and Ca²⁺-phosphate product. These alterations can be deleterious to bone mineral metabolism and soft tissue health, leading to metabolic bone disease and vascular calcification and aging, termed CKD-mineral and bone disorder (MBD). CKD-MBD is associated with morbid clinical outcomes, including fracture, cardiovascular events and all-cause mortality. In this paper, we comprehensively review Ca²⁺ regulation and bone mineral metabolism, with a special emphasis on elderly CKD patients. We also present the current treatment-guidelines and management options for CKD-MBD.

Original language	English (US)
Pages (from-to)	1913-1936
Number of pages	24
Journal	Nutrients
Volume	5
Issue number	6
DOIs	https://doi.org/10.3390/nu5061913
State	Published - May 29 2013

Keywords

Aging
Calcium homeostasis
Chronic kidney disease
Mineral and bone disorder
Secondary hyperparathyroidism
Vascular calcification

ASJC Scopus subject areas

Food Science
Nutrition and Dietetics

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10.3390/nu5061913

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AB - The elderly chronic kidney disease (CKD) population is growing. Both aging and CKD can disrupt calcium (Ca2+) homeostasis and cause alterations of multiple Ca2+-regulatory mechanisms, including parathyroid hormone, vitamin D, fibroblast growth factor-23/Klotho, calcium-sensing receptor and Ca2+-phosphate product. These alterations can be deleterious to bone mineral metabolism and soft tissue health, leading to metabolic bone disease and vascular calcification and aging, termed CKD-mineral and bone disorder (MBD). CKD-MBD is associated with morbid clinical outcomes, including fracture, cardiovascular events and all-cause mortality. In this paper, we comprehensively review Ca2+ regulation and bone mineral metabolism, with a special emphasis on elderly CKD patients. We also present the current treatment-guidelines and management options for CKD-MBD.

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Calcium regulation and bone mineral metabolism in elderly patients with chronic kidney disease

Abstract

Keywords

ASJC Scopus subject areas

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