Calcium regulation and bone mineral metabolism in elderly patients with chronic kidney disease

Vickram Tejwani, Qi Qian

Research output: Contribution to journalReview article

16 Citations (Scopus)

Abstract

The elderly chronic kidney disease (CKD) population is growing. Both aging and CKD can disrupt calcium (Ca2+) homeostasis and cause alterations of multiple Ca2+-regulatory mechanisms, including parathyroid hormone, vitamin D, fibroblast growth factor-23/Klotho, calcium-sensing receptor and Ca2+-phosphate product. These alterations can be deleterious to bone mineral metabolism and soft tissue health, leading to metabolic bone disease and vascular calcification and aging, termed CKD-mineral and bone disorder (MBD). CKD-MBD is associated with morbid clinical outcomes, including fracture, cardiovascular events and all-cause mortality. In this paper, we comprehensively review Ca2+ regulation and bone mineral metabolism, with a special emphasis on elderly CKD patients. We also present the current treatment-guidelines and management options for CKD-MBD.

Original languageEnglish (US)
Pages (from-to)1913-1936
Number of pages24
JournalNutrients
Volume5
Issue number6
DOIs
StatePublished - May 29 2013

Fingerprint

Chronic Kidney Disease-Mineral and Bone Disorder
mineral metabolism
kidney diseases
Chronic Renal Insufficiency
Minerals
bones
Calcium
calcium
Bone and Bones
Vascular Calcification
Calcium-Sensing Receptors
Metabolic Bone Diseases
minerals
Parathyroid Hormone
Vitamin D
Homeostasis
Phosphates
developmental orthopedic disease
Guidelines
fibroblast growth factors

Keywords

  • Aging
  • Calcium homeostasis
  • Chronic kidney disease
  • Mineral and bone disorder
  • Secondary hyperparathyroidism
  • Vascular calcification

ASJC Scopus subject areas

  • Food Science
  • Nutrition and Dietetics

Cite this

Calcium regulation and bone mineral metabolism in elderly patients with chronic kidney disease. / Tejwani, Vickram; Qian, Qi.

In: Nutrients, Vol. 5, No. 6, 29.05.2013, p. 1913-1936.

Research output: Contribution to journalReview article

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