TY - JOUR
T1 - Calcium regulation and bone mineral metabolism in elderly patients with chronic kidney disease
AU - Tejwani, Vickram
AU - Qian, Qi
N1 - Copyright:
Copyright 2018 Elsevier B.V., All rights reserved.
PY - 2013/5/29
Y1 - 2013/5/29
N2 - The elderly chronic kidney disease (CKD) population is growing. Both aging and CKD can disrupt calcium (Ca2+) homeostasis and cause alterations of multiple Ca2+-regulatory mechanisms, including parathyroid hormone, vitamin D, fibroblast growth factor-23/Klotho, calcium-sensing receptor and Ca2+-phosphate product. These alterations can be deleterious to bone mineral metabolism and soft tissue health, leading to metabolic bone disease and vascular calcification and aging, termed CKD-mineral and bone disorder (MBD). CKD-MBD is associated with morbid clinical outcomes, including fracture, cardiovascular events and all-cause mortality. In this paper, we comprehensively review Ca2+ regulation and bone mineral metabolism, with a special emphasis on elderly CKD patients. We also present the current treatment-guidelines and management options for CKD-MBD.
AB - The elderly chronic kidney disease (CKD) population is growing. Both aging and CKD can disrupt calcium (Ca2+) homeostasis and cause alterations of multiple Ca2+-regulatory mechanisms, including parathyroid hormone, vitamin D, fibroblast growth factor-23/Klotho, calcium-sensing receptor and Ca2+-phosphate product. These alterations can be deleterious to bone mineral metabolism and soft tissue health, leading to metabolic bone disease and vascular calcification and aging, termed CKD-mineral and bone disorder (MBD). CKD-MBD is associated with morbid clinical outcomes, including fracture, cardiovascular events and all-cause mortality. In this paper, we comprehensively review Ca2+ regulation and bone mineral metabolism, with a special emphasis on elderly CKD patients. We also present the current treatment-guidelines and management options for CKD-MBD.
KW - Aging
KW - Calcium homeostasis
KW - Chronic kidney disease
KW - Mineral and bone disorder
KW - Secondary hyperparathyroidism
KW - Vascular calcification
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U2 - 10.3390/nu5061913
DO - 10.3390/nu5061913
M3 - Review article
C2 - 23760058
AN - SCOPUS:84878431459
VL - 5
SP - 1913
EP - 1936
JO - Nutrients
JF - Nutrients
SN - 2072-6643
IS - 6
ER -