Calcium-modulated contractile proteins associated with the eucaryotic centrosome.

Jeffrey L Salisbury, A. T. Baron, D. E. Coling, V. E. Martindale, M. A. Sanders

Research output: Contribution to journalArticle

70 Citations (Scopus)

Abstract

Affinity-purified antibodies that recognize the 20,000-dalton molecular weight (20 kd) striated flagellar root protein of Tetraselmis striata have been used to identify antigenic homologs in other eucaryotic organisms of diverse evolutionary origins. Among the green algae, Tetraselmis and Chlamydomonas, and their colorless relative, Polytomella, the 20-kd homologs appear associated with basal bodies. This occurs most prominently in the form of flagellar roots of both striated and microtubule subtended types. Among cultured mammalian cells (PtK2 and primary mouse macrophage cell lines), flagellar root protein homologs appear as basal feet, pericentriolar fibrils, and pericentriolar satellites. Mammalian sperm cells also show flagellar root protein homologs associated with their basal bodies. We envisage a functional role for these fibrous calcium-sensitive contractile proteins in altering the orientation of centrioles or basal bodies with their associated MTOCs by responding to topological calcium fluxes.

Original languageEnglish (US)
Pages (from-to)193-197
Number of pages5
JournalCell Motility and the Cytoskeleton
Volume6
Issue number2
StatePublished - 1986
Externally publishedYes

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Basal Bodies
Contractile Proteins
Centrosome
Calcium
Microtubule-Organizing Center
Centrioles
Chlamydomonas
Chlorophyta
Proteins
Antibody Affinity
Microtubules
Spermatozoa
Foot
Cultured Cells
Molecular Weight
Macrophages
Cell Line

ASJC Scopus subject areas

  • Cell Biology

Cite this

Salisbury, J. L., Baron, A. T., Coling, D. E., Martindale, V. E., & Sanders, M. A. (1986). Calcium-modulated contractile proteins associated with the eucaryotic centrosome. Cell Motility and the Cytoskeleton, 6(2), 193-197.

Calcium-modulated contractile proteins associated with the eucaryotic centrosome. / Salisbury, Jeffrey L; Baron, A. T.; Coling, D. E.; Martindale, V. E.; Sanders, M. A.

In: Cell Motility and the Cytoskeleton, Vol. 6, No. 2, 1986, p. 193-197.

Research output: Contribution to journalArticle

Salisbury, JL, Baron, AT, Coling, DE, Martindale, VE & Sanders, MA 1986, 'Calcium-modulated contractile proteins associated with the eucaryotic centrosome.', Cell Motility and the Cytoskeleton, vol. 6, no. 2, pp. 193-197.
Salisbury, Jeffrey L ; Baron, A. T. ; Coling, D. E. ; Martindale, V. E. ; Sanders, M. A. / Calcium-modulated contractile proteins associated with the eucaryotic centrosome. In: Cell Motility and the Cytoskeleton. 1986 ; Vol. 6, No. 2. pp. 193-197.
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