Calcium dependent protein kinases (CDPKS): Key to malaria eradication

Kavita Kadian; Yash Gupta; Prakasha Kempaiah; Nikesh Gupta; Arun Sharma; Manmeet Rawat

doi:10.2174/1568026617666170130112714

Calcium dependent protein kinases (CDPKS): Key to malaria eradication

Kavita Kadian, Yash Gupta, Prakasha Kempaiah, Nikesh Gupta, Arun Sharma, Manmeet Rawat

Infectious Diseases

Research output: Contribution to journal › Review article › peer-review

Abstract

Introduction: The family of calcium-dependent protein kinases (CDPKs) carries a kinase domain fused to a calmodulin-like domain. The presence of protein kinases devoid of clear mammalian eukaryotic protein kinase orthologues makes them potential targets for therapeutic development. Recent studies on CDPKs have inspired an important primary regulator of calcium (intracellular Ca²⁺ signaling), which is extensively reported to play a critical role in various stages of the apicomplexan life cycle such as microneme secretion of adhesions, cell invasion, gamete maturation, gliding motility and egress of Plasmodium Spp. Conclusion: Understanding and identifying these essential cytoregulatory components of the parasite is important for drug targets development and therapeutic intervention.

Original language	English (US)
Pages (from-to)	2215-2220
Number of pages	6
Journal	Current Topics in Medicinal Chemistry
Volume	17
Issue number	19
DOIs	https://doi.org/10.2174/1568026617666170130112714
State	Published - 2017

Keywords

CDPK
CDPK
Calcium signalling
Drug target
Malaria
Plasmodium parasites

ASJC Scopus subject areas

Drug Discovery

Access to Document

10.2174/1568026617666170130112714

Cite this

@article{67ac1045c8ff4a879c997d13a4ad2e61,

title = "Calcium dependent protein kinases (CDPKS): Key to malaria eradication",

abstract = "Introduction: The family of calcium-dependent protein kinases (CDPKs) carries a kinase domain fused to a calmodulin-like domain. The presence of protein kinases devoid of clear mammalian eukaryotic protein kinase orthologues makes them potential targets for therapeutic development. Recent studies on CDPKs have inspired an important primary regulator of calcium (intracellular Ca2+ signaling), which is extensively reported to play a critical role in various stages of the apicomplexan life cycle such as microneme secretion of adhesions, cell invasion, gamete maturation, gliding motility and egress of Plasmodium Spp. Conclusion: Understanding and identifying these essential cytoregulatory components of the parasite is important for drug targets development and therapeutic intervention.",

keywords = "CDPK, CDPK, Calcium signalling, Drug target, Malaria, Plasmodium parasites",

author = "Kavita Kadian and Yash Gupta and Prakasha Kempaiah and Nikesh Gupta and Arun Sharma and Manmeet Rawat",

note = "Publisher Copyright: {\textcopyright} 2017 Bentham Science Publishers.",

year = "2017",

doi = "10.2174/1568026617666170130112714",

language = "English (US)",

volume = "17",

pages = "2215--2220",

journal = "Current Topics in Medicinal Chemistry",

issn = "1568-0266",

publisher = "Bentham Science Publishers B.V.",

number = "19",

}

TY - JOUR

T1 - Calcium dependent protein kinases (CDPKS)

T2 - Key to malaria eradication

AU - Kadian, Kavita

AU - Gupta, Yash

AU - Kempaiah, Prakasha

AU - Gupta, Nikesh

AU - Sharma, Arun

AU - Rawat, Manmeet

PY - 2017

Y1 - 2017

N2 - Introduction: The family of calcium-dependent protein kinases (CDPKs) carries a kinase domain fused to a calmodulin-like domain. The presence of protein kinases devoid of clear mammalian eukaryotic protein kinase orthologues makes them potential targets for therapeutic development. Recent studies on CDPKs have inspired an important primary regulator of calcium (intracellular Ca2+ signaling), which is extensively reported to play a critical role in various stages of the apicomplexan life cycle such as microneme secretion of adhesions, cell invasion, gamete maturation, gliding motility and egress of Plasmodium Spp. Conclusion: Understanding and identifying these essential cytoregulatory components of the parasite is important for drug targets development and therapeutic intervention.

AB - Introduction: The family of calcium-dependent protein kinases (CDPKs) carries a kinase domain fused to a calmodulin-like domain. The presence of protein kinases devoid of clear mammalian eukaryotic protein kinase orthologues makes them potential targets for therapeutic development. Recent studies on CDPKs have inspired an important primary regulator of calcium (intracellular Ca2+ signaling), which is extensively reported to play a critical role in various stages of the apicomplexan life cycle such as microneme secretion of adhesions, cell invasion, gamete maturation, gliding motility and egress of Plasmodium Spp. Conclusion: Understanding and identifying these essential cytoregulatory components of the parasite is important for drug targets development and therapeutic intervention.

KW - CDPK

KW - Calcium signalling

KW - Drug target

KW - Malaria

KW - Plasmodium parasites

UR - http://www.scopus.com/inward/record.url?scp=85021180099&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85021180099&partnerID=8YFLogxK

U2 - 10.2174/1568026617666170130112714

DO - 10.2174/1568026617666170130112714

M3 - Review article

C2 - 28137235

AN - SCOPUS:85021180099

SN - 1568-0266

VL - 17

SP - 2215

EP - 2220

JO - Current Topics in Medicinal Chemistry

JF - Current Topics in Medicinal Chemistry

IS - 19

ER -

Calcium dependent protein kinases (CDPKS): Key to malaria eradication

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this