Calcium dependent protein kinases (CDPKS): Key to malaria eradication

Kavita Kadian, Yash Gupta, Prakasha Kempaiah, Nikesh Gupta, Arun Sharma, Manmeet Rawat

Research output: Contribution to journalReview articlepeer-review

Abstract

Introduction: The family of calcium-dependent protein kinases (CDPKs) carries a kinase domain fused to a calmodulin-like domain. The presence of protein kinases devoid of clear mammalian eukaryotic protein kinase orthologues makes them potential targets for therapeutic development. Recent studies on CDPKs have inspired an important primary regulator of calcium (intracellular Ca2+ signaling), which is extensively reported to play a critical role in various stages of the apicomplexan life cycle such as microneme secretion of adhesions, cell invasion, gamete maturation, gliding motility and egress of Plasmodium Spp. Conclusion: Understanding and identifying these essential cytoregulatory components of the parasite is important for drug targets development and therapeutic intervention.

Original languageEnglish (US)
Pages (from-to)2215-2220
Number of pages6
JournalCurrent Topics in Medicinal Chemistry
Volume17
Issue number19
DOIs
StatePublished - 2017

Keywords

  • Calcium signalling
  • CDPK
  • CDPK
  • Drug target
  • Malaria
  • Plasmodium parasites

ASJC Scopus subject areas

  • Drug Discovery

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