CAD of colon cancer on CT colonography cases without cathartic bowel preparation

Marius George Linguraru, Shan Zhao, Robert L. Van Uitert, Jiamin Liu, Joel Garland Fletcher, Armando Manduca, Ronald M. Summers

Research output: Chapter in Book/Report/Conference proceedingConference contribution

6 Scopus citations

Abstract

Computer-aided diagnosis (CAD) systems must show sufficient versatility to produce robust analysis on a large variety of data. In the case of colonography, CAD has not been designed to cope with the presence of stool, although labeling the stool with high contrast agents replaces the use of laxatives and reduces the patient discomfort. This procedure introduces additional challenges for the diagnosis, such as poorly tagged stool, stool sticking to colonic walls, and heterogeneous stool (tagged stool mixed with air or untagged stool). Our study proposes a robust algorithm for heterogeneous stool removal to be employed as a preprocessing module for CAD systems in colonic cancer detection. Colonoscopy data are automatically cleansed of residual stool to enhance the polyp appearance for improved diagnosis. The algorithm uses expectationmaximization, quadratic regression, level sets and minimum variance. Results show stool removal accuracy on polyps which are partially or fully covered by stool. The results are robust on stool lining and large pools of heterogeneous and weakly-tagged stool. The automatic detection of colon polyps using our CAD system on cathartic-free data improves considerably with the addition of the automatic stool removal module from 74% to 86% true positive (TP) rate at 6.4 false positives (FP)/case.

Original languageEnglish (US)
Title of host publicationProceedings of the 30th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS'08 - "Personalized Healthcare through Technology"
Pages2996-2999
Number of pages4
StatePublished - 2008
Event30th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS'08 - Vancouver, BC, Canada
Duration: Aug 20 2008Aug 25 2008

Other

Other30th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS'08
CountryCanada
CityVancouver, BC
Period8/20/088/25/08

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ASJC Scopus subject areas

  • Computer Vision and Pattern Recognition
  • Signal Processing
  • Biomedical Engineering
  • Health Informatics

Cite this

Linguraru, M. G., Zhao, S., Van Uitert, R. L., Liu, J., Fletcher, J. G., Manduca, A., & Summers, R. M. (2008). CAD of colon cancer on CT colonography cases without cathartic bowel preparation. In Proceedings of the 30th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS'08 - "Personalized Healthcare through Technology" (pp. 2996-2999). [4649833]