Cachexia in rheumatoid arthritis is not explained by decreased growth hormone secretion

Laura C. Rall, Joseph M. Walsmith, Laura Snydman, Seymour Reichlin, Johannes D Veldhuis, Joseph J. Kehayias, Leslie W. Abad, Nancy T. Lundgren, Ronenn Roubenoff

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

Objective. Patients with rheumatoid arthritis (RA) lose body cell mass (BCM) by unknown mechanisms. Since the loss of BCM in normal aging individuals parallels the characteristic age-related decline in growth hormone (GH) secretion, this study was carried out to determine whether further decreased GH secretion plays a role in the pathogenesis of this loss of BCM in RA patients, termed "rheumatoid cachexia." Methods. GH secretory kinetics were determined by deconvolution analysis in 16 patients with RA and 17 healthy controls matched for age (mean ± SD 45.4 ± 13.2 years and 47.1 ± 14.6 years, respectively), sex, race, and body mass index. Blood samples were obtained every 20 minutes for 24 hours. Body composition was ascertained using total-body potassium (TBK) as a measure of BCM and dual x-ray absorptiometry to determine fat mass. Results. BCM was reduced in patients with RA compared with healthy controls (mean ± SD gm TBK 79.5 ± 9.5 versus 94.9 ± 11.9; P ± 0.0005), but there was no difference in fat mass. GH kinetic parameters in patients with RA did not differ from those in controls. Conclusion. These findings suggest that GH kinetics are unaltered in RA patients compared with healthy subjects; thus, GH deficiency does not account for rheumatoid cachexia.

Original languageEnglish (US)
Pages (from-to)2574-2577
Number of pages4
JournalArthritis and Rheumatism
Volume46
Issue number10
DOIs
StatePublished - Oct 1 2002

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Cachexia
Growth Hormone
Rheumatoid Arthritis
Fats
Body Weights and Measures
Body Composition
Healthy Volunteers
Potassium
Body Mass Index
X-Rays

ASJC Scopus subject areas

  • Immunology
  • Rheumatology

Cite this

Rall, L. C., Walsmith, J. M., Snydman, L., Reichlin, S., Veldhuis, J. D., Kehayias, J. J., ... Roubenoff, R. (2002). Cachexia in rheumatoid arthritis is not explained by decreased growth hormone secretion. Arthritis and Rheumatism, 46(10), 2574-2577. https://doi.org/10.1002/art.10714

Cachexia in rheumatoid arthritis is not explained by decreased growth hormone secretion. / Rall, Laura C.; Walsmith, Joseph M.; Snydman, Laura; Reichlin, Seymour; Veldhuis, Johannes D; Kehayias, Joseph J.; Abad, Leslie W.; Lundgren, Nancy T.; Roubenoff, Ronenn.

In: Arthritis and Rheumatism, Vol. 46, No. 10, 01.10.2002, p. 2574-2577.

Research output: Contribution to journalArticle

Rall, LC, Walsmith, JM, Snydman, L, Reichlin, S, Veldhuis, JD, Kehayias, JJ, Abad, LW, Lundgren, NT & Roubenoff, R 2002, 'Cachexia in rheumatoid arthritis is not explained by decreased growth hormone secretion', Arthritis and Rheumatism, vol. 46, no. 10, pp. 2574-2577. https://doi.org/10.1002/art.10714
Rall LC, Walsmith JM, Snydman L, Reichlin S, Veldhuis JD, Kehayias JJ et al. Cachexia in rheumatoid arthritis is not explained by decreased growth hormone secretion. Arthritis and Rheumatism. 2002 Oct 1;46(10):2574-2577. https://doi.org/10.1002/art.10714
Rall, Laura C. ; Walsmith, Joseph M. ; Snydman, Laura ; Reichlin, Seymour ; Veldhuis, Johannes D ; Kehayias, Joseph J. ; Abad, Leslie W. ; Lundgren, Nancy T. ; Roubenoff, Ronenn. / Cachexia in rheumatoid arthritis is not explained by decreased growth hormone secretion. In: Arthritis and Rheumatism. 2002 ; Vol. 46, No. 10. pp. 2574-2577.
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