C825T polymorphism of the G protein β3-subunit and antihypertensive response to a thiazide diuretic

Stephen T. Turner, Gary L. Schwartz, Arlene B. Chapman, Eric Boerwinkle

Research output: Contribution to journalArticlepeer-review

188 Scopus citations

Abstract

The T allele of the C825T polymorphism of the gene encoding the β3-subunit of G proteins has been associated with increased sodium-hydrogen exchange and low renin in patients with essential hypertension. To assess its association with blood pressure response to diuretic therapy, we measured the C825T polymorphism in 197 blacks (134 men, 63 women) and 190 non-Hispanic whites (76 men, 114 women) with essential hypertension (mean±SD age 48±7 years), who underwent monotherapy with hydrochlorothiazide for 4 weeks. Mean declines in systolic and diastolic blood pressures were 6±2 (P<0.001) and 5±1 (P<0.001) mm Hg greater, respectively, in TT than in CC homozygotes. Responses in heterozygotes were intermediate between the homozygous groups. Other univariate predictors of greater blood pressure responses included black race, female gender, higher pretreatment blood pressure, older age, lower waist-to-hip ratio, and measures of lower renin-angiotensin-aldosterone system activity. After the effects of the other predictors were considered, the TT genotype remained a significant predictor of greater declines in systolic and diastolic blood pressures. Thus, the C825T polymorphism of the G protein β3-subunit may help identify patients with essential hypertension who are more responsive to diuretic therapy.

Original languageEnglish (US)
Pages (from-to)739-743
Number of pages5
JournalHypertension
Volume37
Issue number2 II
DOIs
StatePublished - 2001

Keywords

  • Blood pressure
  • Diuretics
  • Essential
  • Genetics
  • Hypertension
  • Proteins

ASJC Scopus subject areas

  • Internal Medicine

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