C3 glomerulopathy: Consensus report

Matthew C. Pickering, Vivette D. D'agati, Carla M. Nester, Richard J. Smith, Mark Haas, Gerald B. Appel, Charles E. Alpers, Ingeborg M. Bajema, Camille Bedrosian, Michael Braun, Mittie Doyle, Fadi Fakhouri, Fernando C. Fervenza, Agnes B. Fogo, Véronique Frémeaux-Bacchi, Daniel P. Gale, Elena Goicoechea De Jorge, Gene Griffin, Claire L. Harris, V. Michael HolersSally Johnson, Peter J. Lavin, Nicholas Medjeral-Thomas, B. Paul Morgan, Cynthia C. Nast, Laure Hélène Noel, D. Keith Peters, Santiago Rodríguez De Córdoba, Aude Servais, Sanjeev Sethi, Wen Chao Song, Paul Tamburini, Joshua M. Thurman, Michael Zavros, H. Terence Cook

Research output: Contribution to journalArticle

283 Scopus citations

Abstract

C3 glomerulopathy is a recently introduced pathological entity whose original definition was glomerular pathology characterized by C3 accumulation with absent or scanty immunoglobulin deposition. In August 2012, an invited group of experts (comprising the authors of this document) in renal pathology, nephrology, complement biology, and complement therapeutics met to discuss C3 glomerulopathy in the first C3 Glomerulopathy Meeting. The objectives were to reach a consensus on: the definition of C3 glomerulopathy, appropriate complement investigations that should be performed in these patients, and how complement therapeutics should be explored in the condition. This meeting report represents the current consensus view of the group.

Original languageEnglish (US)
Pages (from-to)1079-1089
Number of pages11
JournalKidney international
Volume84
Issue number6
DOIs
StatePublished - Dec 2013

Keywords

  • clinical immunology
  • clinical nephrology
  • complement
  • glomerulonephritis
  • immunology and pathology

ASJC Scopus subject areas

  • Nephrology

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    Pickering, M. C., D'agati, V. D., Nester, C. M., Smith, R. J., Haas, M., Appel, G. B., Alpers, C. E., Bajema, I. M., Bedrosian, C., Braun, M., Doyle, M., Fakhouri, F., Fervenza, F. C., Fogo, A. B., Frémeaux-Bacchi, V., Gale, D. P., Goicoechea De Jorge, E., Griffin, G., Harris, C. L., ... Cook, H. T. (2013). C3 glomerulopathy: Consensus report. Kidney international, 84(6), 1079-1089. https://doi.org/10.1038/ki.2013.377