C-type natriuretic peptide immunoreactivity in human breast vascular endothelial cells

Denise M. Heublein, Alfredo L. Clavell, Andrew J. Stingo, Amir Lerman, Lester Wold, John C. Burnett

Research output: Contribution to journalArticle

47 Scopus citations

Abstract

The present study was undertaken to determine the presence of CNP immunoreactivity in human breast tissue (n = 9). Immunohistochemical staining of breast tissue revealed the presence of CNP immunoreactivity localized to vascular endothelial cells. This study demonstrates for the first time that CNP immunoreactivity is present in humans. Based upon the known biological actions of CNP, these findings suggest that CNP may function as part of an endothelium-derived vasoregulatory system.

Original languageEnglish (US)
Pages (from-to)1017-1019
Number of pages3
JournalPeptides
Volume13
Issue number5
DOIs
StatePublished - Jan 1 1992

Keywords

  • Endothelium
  • Immunohistochemistry
  • Natriuretic peptides
  • Vascular tone

ASJC Scopus subject areas

  • Biochemistry
  • Physiology
  • Endocrinology
  • Cellular and Molecular Neuroscience

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