C-Type Lectin-like Receptor LOX-1 Promotes Dendritic Cell-Mediated Class-Switched B Cell Responses

Hye Mee Joo, Dapeng Li, Melissa Dullaers, Tae Whan Kim, Dorothee Duluc, Katherine Upchurch, Yaming Xue, Sandy Zurawski, Roger LeGrand, Yong Jun Liu, Marcelo Kuroda, Gerard Zurawski, Sang Kon Oh

Research output: Contribution to journalArticle

30 Scopus citations

Abstract

Lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) is a pattern-recognition receptor for a variety of endogenous and exogenous ligands. However, LOX-1 function in the host immune response is not fully understood. Here, we report that LOX-1 expressed on dendritic cells (DCs) and B cells promotes humoral responses. On B cells LOX-1 signaling upregulated CCR7, promoting cellular migration toward lymphoid tissues. LOX-1 signaling on DCs licensed the cells to promote B cell differentiation into class-switched plasmablasts and led to downregulation of chemokine receptor CXCR5 and upregulation ofchemokine receptor CCR10 on plasmablasts, enabling their exit from germinal centers and migration toward local mucosa and skin. Finally, we foundthat targeting influenza hemagglutinin 1 (HA1) subunit toLOX-1 elicited HA1-specific protectiveantibody responses in rhesus macaques. Thus, LOX-1 expressed on B cells and DC cells has complementary functions to promote humoral immune responses.

Original languageEnglish (US)
Pages (from-to)592-604
Number of pages13
JournalImmunity
Volume41
Issue number4
DOIs
StatePublished - Oct 16 2014

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Infectious Diseases

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    Joo, H. M., Li, D., Dullaers, M., Kim, T. W., Duluc, D., Upchurch, K., Xue, Y., Zurawski, S., LeGrand, R., Liu, Y. J., Kuroda, M., Zurawski, G., & Oh, S. K. (2014). C-Type Lectin-like Receptor LOX-1 Promotes Dendritic Cell-Mediated Class-Switched B Cell Responses. Immunity, 41(4), 592-604. https://doi.org/10.1016/j.immuni.2014.09.009