Abstract
Lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) is a pattern-recognition receptor for a variety of endogenous and exogenous ligands. However, LOX-1 function in the host immune response is not fully understood. Here, we report that LOX-1 expressed on dendritic cells (DCs) and B cells promotes humoral responses. On B cells LOX-1 signaling upregulated CCR7, promoting cellular migration toward lymphoid tissues. LOX-1 signaling on DCs licensed the cells to promote B cell differentiation into class-switched plasmablasts and led to downregulation of chemokine receptor CXCR5 and upregulation ofchemokine receptor CCR10 on plasmablasts, enabling their exit from germinal centers and migration toward local mucosa and skin. Finally, we foundthat targeting influenza hemagglutinin 1 (HA1) subunit toLOX-1 elicited HA1-specific protectiveantibody responses in rhesus macaques. Thus, LOX-1 expressed on B cells and DC cells has complementary functions to promote humoral immune responses.
Original language | English (US) |
---|---|
Pages (from-to) | 592-604 |
Number of pages | 13 |
Journal | Immunity |
Volume | 41 |
Issue number | 4 |
DOIs | |
State | Published - Oct 16 2014 |
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology
- Infectious Diseases