TY - JOUR
T1 - C-reactive protein is related to arterial wave reflection and stiffness in asymptomatic subjects from the community
AU - Kullo, Iftikhar J.
AU - Seward, James B.
AU - Bailey, Kent R.
AU - Bielak, Lawrence F.
AU - Grossardt, Brandon R.
AU - Sheedy, Patrick F.
AU - Peyser, Patricia A.
AU - Turner, Stephen T.
N1 - Funding Information:
This work was supported by: a Mentored Patient-Oriented Research Career Development Award (K-23, RR17720) from the National Center for Research Resources to I.J.K, by Grant R01 HL46292, and the General Clinical Research Center Grant M01 RR00585 from National Institutes of Health.
PY - 2005/8
Y1 - 2005/8
N2 - Background: Emerging data suggest that C-reactive protein (CRP), a marker of inflammation, is associated with functional properties of arteries. We investigated the relationship of CRP to measures of arterial wave reflection and stiffness (aortic augmentation index [AIX], carotid-femoral pulse wave velocity [PWV], and pulse pressure) in asymptomatic individuals from the community. Methods: Subjects (n = 214) had a mean age of 59 years and 53% were men. CRP was measured by a high-sensitivity assay and values were log-transformed to reduce skewness. Radial artery waveforms were obtained by applanation tonometry, a validated transfer function was used to derive an ascending aortic pressure waveform, and AIX calculated. PWV was calculated from electrocardiogram-gated waveforms of the right carotid and right femoral artery obtained by applanation tonometry. Results: Log CRP was correlated with AIX (r = 0.24, P = .0005), PWV (r = 0.25, P = .0002), and pulse pressure (r = 0.29, P ≤ .0001). In separate backward elimination multiple regression analyses, log CRP was significantly associated with AIX (P = .038) and pulse pressure (P = .036), and marginally significantly associated with PWV (P = .054), after adjustment for heart rate, height, and coronary heart disease (CHD) risk factors (age, sex, body mass index, mean arterial pressure, total cholesterol, HDL cholesterol, diabetes, hypertension, and history of smoking). Conclusions: These results suggest that CRP, a marker of systemic inflammation, is related to measures of arterial wave reflection and stiffness in asymptomatic subjects from the community. Further studies are needed to understand the mechanisms underlying this association and the implications for assessment and management of CHD risk.
AB - Background: Emerging data suggest that C-reactive protein (CRP), a marker of inflammation, is associated with functional properties of arteries. We investigated the relationship of CRP to measures of arterial wave reflection and stiffness (aortic augmentation index [AIX], carotid-femoral pulse wave velocity [PWV], and pulse pressure) in asymptomatic individuals from the community. Methods: Subjects (n = 214) had a mean age of 59 years and 53% were men. CRP was measured by a high-sensitivity assay and values were log-transformed to reduce skewness. Radial artery waveforms were obtained by applanation tonometry, a validated transfer function was used to derive an ascending aortic pressure waveform, and AIX calculated. PWV was calculated from electrocardiogram-gated waveforms of the right carotid and right femoral artery obtained by applanation tonometry. Results: Log CRP was correlated with AIX (r = 0.24, P = .0005), PWV (r = 0.25, P = .0002), and pulse pressure (r = 0.29, P ≤ .0001). In separate backward elimination multiple regression analyses, log CRP was significantly associated with AIX (P = .038) and pulse pressure (P = .036), and marginally significantly associated with PWV (P = .054), after adjustment for heart rate, height, and coronary heart disease (CHD) risk factors (age, sex, body mass index, mean arterial pressure, total cholesterol, HDL cholesterol, diabetes, hypertension, and history of smoking). Conclusions: These results suggest that CRP, a marker of systemic inflammation, is related to measures of arterial wave reflection and stiffness in asymptomatic subjects from the community. Further studies are needed to understand the mechanisms underlying this association and the implications for assessment and management of CHD risk.
KW - Augmentation index
KW - C-reactive protein
KW - Inflammation
KW - Pulse pressure
KW - Pulse wave velocity
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U2 - 10.1016/j.amjhyper.2005.03.730
DO - 10.1016/j.amjhyper.2005.03.730
M3 - Article
C2 - 16109328
AN - SCOPUS:23744506024
SN - 0895-7061
VL - 18
SP - 1123
EP - 1129
JO - American journal of hypertension
JF - American journal of hypertension
IS - 8
ER -