c-Myc oncoprotein: cell cycle-related events and new therapeutic challenges in cancer and cardiovascular diseases.

Filomena de Nigris, Vincenzo Sica, Joerg Herrmann, Gianluigi Condorelli, Alejandro R. Chade, Gianfranco Tajana, Amir Lerman, Lilach O. Lerman, Claudio Napoli

Research output: Contribution to journalReview article

35 Scopus citations

Abstract

Advanced stages of both cancer and atherosclerosis are characterized by a local increase in tissue mass that may be hard to control. This increase in tissue mass can be attributed to oxidation-sensitive modification of cell cycle-related events, including cellular proliferation, differentiation, and apoptosis, which could be secondary to alteration in the activity of tumor suppressor gene and oncogene products. The oncogene c-Myc has classically been considered to be involved in carcinogenesis and has more recently been implicated in both endothelial dysfunction and atherogenesis as well. Consequently, inhibition of c-Myc-dependent signaling has become a novel therapeutic opportunity and challenge in atherosclerosis and other cardiovascular diseases. Antioxidant strategies, RNA synthesis inhibitors such as mithramycin, and gene therapeutic approaches with antisense oligonucleotides against c-Myc are some of the promising strategies. In general, the increased biologic understanding of the participation of cell cycle events and targeting these events may enable to attenuate or prevent some of the complications of vascular and neoplastic diseases.

Original languageEnglish (US)
Pages (from-to)325-328
Number of pages4
JournalCell cycle (Georgetown, Tex.)
Volume2
Issue number4
StatePublished - Jan 1 2003

ASJC Scopus subject areas

  • Molecular Biology
  • Developmental Biology
  • Cell Biology

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