c-Myc oncoprotein: A dual pathogenic role in neoplasia and cardiovascular diseases?

Claudio Napoli, Lilach O. Lerman, Filomena De Nigris, Vincenzo Sica

Research output: Contribution to journalReview article

22 Scopus citations

Abstract

A growing body of evidence indicates that c-Myc can play a pivotal role both in neoplasia and cardiovascular diseases. Indeed, alterations of the basal machinery of the cell and perturbations of c-Myc-dependent signaling network are involved in the pathogenesis of certain cardiovascular disorders. Down-regulation of c-Myc induced by intervention with antioxidants or by antisense technology may protect the integrity of the arterial wall as well as neoplastic tissues. Further intervention studies are necessary to investigate the effects of tissue-specific block of c-Myc overexpression in the development of cardiovascular diseases.

Original languageEnglish (US)
Pages (from-to)185-190
Number of pages6
JournalNeoplasia
Volume4
Issue number3
DOIs
StatePublished - May 28 2002

Keywords

  • Artery
  • Atherosclerosis
  • Cancer
  • Heart
  • c-Myc

ASJC Scopus subject areas

  • Cancer Research

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