C-lysine conjugates: pH-controlled light-activated reagents for efficient double-stranded DNA cleavage with implications for cancer therapy

Wang Yong Yang, Boris Breiner, Serguei V. Kovalenko, Chi Ben, Mani Singh, Shauna N. LeGrand, Qing Xiang Amy Sang, Geoffrey F. Strouse, John A III Copland, Igor V. Alabugin

Research output: Contribution to journalArticle

53 Citations (Scopus)

Abstract

Double-stranded DNA cleavage of light-activated lysine conjugates is strongly enhanced at the slightly acidic pH (

Original languageEnglish (US)
Pages (from-to)11458-11470
Number of pages13
JournalJournal of the American Chemical Society
Volume131
Issue number32
DOIs
StatePublished - Aug 19 2009

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DNA Cleavage
Lysine
DNA
Light
Neoplasms
Therapeutics

ASJC Scopus subject areas

  • Chemistry(all)
  • Catalysis
  • Biochemistry
  • Colloid and Surface Chemistry

Cite this

C-lysine conjugates : pH-controlled light-activated reagents for efficient double-stranded DNA cleavage with implications for cancer therapy. / Yang, Wang Yong; Breiner, Boris; Kovalenko, Serguei V.; Ben, Chi; Singh, Mani; LeGrand, Shauna N.; Sang, Qing Xiang Amy; Strouse, Geoffrey F.; Copland, John A III; Alabugin, Igor V.

In: Journal of the American Chemical Society, Vol. 131, No. 32, 19.08.2009, p. 11458-11470.

Research output: Contribution to journalArticle

Yang, WY, Breiner, B, Kovalenko, SV, Ben, C, Singh, M, LeGrand, SN, Sang, QXA, Strouse, GF, Copland, JAIII & Alabugin, IV 2009, 'C-lysine conjugates: pH-controlled light-activated reagents for efficient double-stranded DNA cleavage with implications for cancer therapy', Journal of the American Chemical Society, vol. 131, no. 32, pp. 11458-11470. https://doi.org/10.1021/ja902140m
Yang, Wang Yong ; Breiner, Boris ; Kovalenko, Serguei V. ; Ben, Chi ; Singh, Mani ; LeGrand, Shauna N. ; Sang, Qing Xiang Amy ; Strouse, Geoffrey F. ; Copland, John A III ; Alabugin, Igor V. / C-lysine conjugates : pH-controlled light-activated reagents for efficient double-stranded DNA cleavage with implications for cancer therapy. In: Journal of the American Chemical Society. 2009 ; Vol. 131, No. 32. pp. 11458-11470.
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