Burden of liver diseases in the world

Sumeet K. Asrani, Harshad Devarbhavi, John Eaton, Patrick Sequeira Kamath

Research output: Contribution to journalArticle

83 Citations (Scopus)

Abstract

Liver disease accounts for approximately 2 million deaths per year worldwide, 1 million due to complications of cirrhosis and 1 million due to viral hepatitis and hepatocellular carcinoma. Cirrhosis is currently the 11th most common cause of death globally and liver cancer is the 16th leading cause of death; combined, they account for 3.5% of all deaths worldwide. Cirrhosis is within the top 20 causes of disability-adjusted life years and years of life lost, accounting for 1.6% and 2.1% of the worldwide burden. About 2 billion people consume alcohol worldwide and upwards of 75 million are diagnosed with alcohol-use disorders and are at risk of alcohol-associated liver disease. Approximately 2 billion adults are obese or overweight and over 400 million have diabetes; both of which are risk factors for non-alcoholic fatty liver disease and hepatocellular carcinoma. The global prevalence of viral hepatitis remains high, while drug-induced liver injury continues to increase as a major cause of acute hepatitis. Liver transplantation is the second most common solid organ transplantation, yet less than 10% of global transplantation needs are met at current rates. Though these numbers are sobering, they highlight an important opportunity to improve public health given that most causes of liver diseases are preventable.

Original languageEnglish (US)
JournalJournal of Hepatology
DOIs
StateAccepted/In press - Jan 1 2018

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Hepatitis
Liver Diseases
Fibrosis
Alcohols
Cause of Death
Hepatocellular Carcinoma
Chemical and Drug Induced Liver Injury
Quality-Adjusted Life Years
Organ Transplantation
Liver Neoplasms
Liver Transplantation
Public Health
Transplantation
Non-alcoholic Fatty Liver Disease

Keywords

  • Burden
  • Chronic liver disease

ASJC Scopus subject areas

  • Hepatology

Cite this

Burden of liver diseases in the world. / Asrani, Sumeet K.; Devarbhavi, Harshad; Eaton, John; Kamath, Patrick Sequeira.

In: Journal of Hepatology, 01.01.2018.

Research output: Contribution to journalArticle

Asrani, Sumeet K. ; Devarbhavi, Harshad ; Eaton, John ; Kamath, Patrick Sequeira. / Burden of liver diseases in the world. In: Journal of Hepatology. 2018.
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