Brunner's gland hamartomas: Clinical presentation and pathological features of 27 cases

James A. Levine, L. J. Burgart, K. P. Batts, Kenneth Ke Ning Wang

Research output: Contribution to journalArticle

135 Citations (Scopus)

Abstract

Objectives: The aim of this study was to characterize the clinical presentation, pathological features, and outcome of a series of patients with Brunner's gland hamartomas. Methods: We reviewed the clinical and pathological features of 27 patients who presented with Brunner's gland hamartomas, and we obtained follow-up information. Results: Patients (12 men and 15 women) presented predominantly in the fifth and sixth decades of life either with gastrointestinal hemorrhage (n = 10) or obstructive symptoms (n = 10); there were also patients whose tumors were discovered as an incidental finding (n = 7). The tumors were generally pedunculated, were located in the first portion of the duodenum, and were in the range of diameter from 1 to 6 cm. Histologically, the hamartomas were characterized by the presence of nondysplastic, lobulated Brunner's glands with intervening bands of fibrous tissue and variable adipose and lymphoid tissue. Focal sclerosis was found in 93% of the hamartomas, possibly mimicking an adenocarcinoma. Whether managed surgically (24 patients) or endoscopically (three patients), the outcome was uniformly favorable. After a median period of 7-yr-follow-up, no tumors recurred, and no additional morbidity was identified. Conclusions: Brunner's gland hamartomas are rare duodenal tumors occurring in middle age that present either with gastrointestinal hemorrhage, obstructive symptoms, or as an incidental finding. Surgical or endoscopic excision is uncomplicated, and the long-term outcome is favorable.

Original languageEnglish (US)
Pages (from-to)290-294
Number of pages5
JournalAmerican Journal of Gastroenterology
Volume90
Issue number2
StatePublished - 1995

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Brunner Glands
Hamartoma
Incidental Findings
Gastrointestinal Hemorrhage
Neoplasms
Sclerosis
Lymphoid Tissue
Duodenum
Adipose Tissue
Adenocarcinoma
Morbidity

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Brunner's gland hamartomas : Clinical presentation and pathological features of 27 cases. / Levine, James A.; Burgart, L. J.; Batts, K. P.; Wang, Kenneth Ke Ning.

In: American Journal of Gastroenterology, Vol. 90, No. 2, 1995, p. 290-294.

Research output: Contribution to journalArticle

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