BRSK2 is activated by cyclic AMP-dependent protein kinase A through phosphorylation at Thr260

Zekun Guo, Wenwen Tang, Jian Yuan, Xinya Chen, Bo Wan, Xiuting Gu, Kuntian Luo, Yingli Wang, Long Yu

Research output: Contribution to journalArticle

13 Scopus citations

Abstract

Brain selective kinase 2 (BRSK2) has been identified as a member of AMPK related kinases. LKB1 can phosphorylate the Thr174 of BRSK2, increasing its activity >50-fold. In this study, we identified cAMP-dependent protein kinase A (PKA) as another upstream kinase of BRSK2, which can phosphorylate BRSK2 at Thr260. The association between these two proteins was confirmed by GST pull-down. Furthermore, our study indicated that the kinase activity of BRSK2 can be increased through phosphorylation by PKA.

Original languageEnglish (US)
Pages (from-to)867-871
Number of pages5
JournalBiochemical and Biophysical Research Communications
Volume347
Issue number4
DOIs
StatePublished - Sep 8 2006

Keywords

  • AMPK subfamily
  • BRSK2
  • PKA
  • Phosphorylation

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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