Bronchoscopic Phototherapy With Hematoporphyrin Derivative for Treatment of Localized Bronchogenic Carcinoma: A 5-Year Experience

Eric Edell, DENIS A. CORTESE

Research output: Contribution to journalArticle

105 Citations (Scopus)

Abstract

Between December 1980 and April 1986 at our institution, 38 patients with cancer that involved the tracheobronchial tree (a total of 40 carcinomas) completed at least one course of hematoporphyrin derivative phototherapy. A complete response occurred in 13 patients (with 14 carcinomas). Eleven of these carcinomas did not recur during follow-up periods that ranged from 3 to 53 months. Three carcinomas recurred at 9, 12, and 35 months, respectively. For 26 carcinomas, the response was less than complete, and alternative therapy was necessary. The carcinomas in patients with a complete response were radiographically occult, were less than 3 cm2 in surface area, and appeared superficial at bronchoscopy. Our experience supports the use of hematoporphyrin derivative phototherapy as an alternative to surgical resection in carefully selected patients.

Original languageEnglish (US)
Pages (from-to)8-14
Number of pages7
JournalMayo Clinic Proceedings
Volume62
Issue number1
DOIs
StatePublished - Jan 1 1987
Externally publishedYes

Fingerprint

Hematoporphyrin Derivative
Phototherapy
Bronchogenic Carcinoma
Carcinoma
Therapeutics
Bronchoscopy
Complementary Therapies

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Bronchoscopic Phototherapy With Hematoporphyrin Derivative for Treatment of Localized Bronchogenic Carcinoma : A 5-Year Experience. / Edell, Eric; CORTESE, DENIS A.

In: Mayo Clinic Proceedings, Vol. 62, No. 1, 01.01.1987, p. 8-14.

Research output: Contribution to journalArticle

@article{f6cbbec0dca64104b999e655c40fe035,
title = "Bronchoscopic Phototherapy With Hematoporphyrin Derivative for Treatment of Localized Bronchogenic Carcinoma: A 5-Year Experience",
abstract = "Between December 1980 and April 1986 at our institution, 38 patients with cancer that involved the tracheobronchial tree (a total of 40 carcinomas) completed at least one course of hematoporphyrin derivative phototherapy. A complete response occurred in 13 patients (with 14 carcinomas). Eleven of these carcinomas did not recur during follow-up periods that ranged from 3 to 53 months. Three carcinomas recurred at 9, 12, and 35 months, respectively. For 26 carcinomas, the response was less than complete, and alternative therapy was necessary. The carcinomas in patients with a complete response were radiographically occult, were less than 3 cm2 in surface area, and appeared superficial at bronchoscopy. Our experience supports the use of hematoporphyrin derivative phototherapy as an alternative to surgical resection in carefully selected patients.",
author = "Eric Edell and CORTESE, {DENIS A.}",
year = "1987",
month = "1",
day = "1",
doi = "10.1016/S0025-6196(12)61520-1",
language = "English (US)",
volume = "62",
pages = "8--14",
journal = "Mayo Clinic Proceedings",
issn = "0025-6196",
publisher = "Elsevier Science",
number = "1",

}

TY - JOUR

T1 - Bronchoscopic Phototherapy With Hematoporphyrin Derivative for Treatment of Localized Bronchogenic Carcinoma

T2 - A 5-Year Experience

AU - Edell, Eric

AU - CORTESE, DENIS A.

PY - 1987/1/1

Y1 - 1987/1/1

N2 - Between December 1980 and April 1986 at our institution, 38 patients with cancer that involved the tracheobronchial tree (a total of 40 carcinomas) completed at least one course of hematoporphyrin derivative phototherapy. A complete response occurred in 13 patients (with 14 carcinomas). Eleven of these carcinomas did not recur during follow-up periods that ranged from 3 to 53 months. Three carcinomas recurred at 9, 12, and 35 months, respectively. For 26 carcinomas, the response was less than complete, and alternative therapy was necessary. The carcinomas in patients with a complete response were radiographically occult, were less than 3 cm2 in surface area, and appeared superficial at bronchoscopy. Our experience supports the use of hematoporphyrin derivative phototherapy as an alternative to surgical resection in carefully selected patients.

AB - Between December 1980 and April 1986 at our institution, 38 patients with cancer that involved the tracheobronchial tree (a total of 40 carcinomas) completed at least one course of hematoporphyrin derivative phototherapy. A complete response occurred in 13 patients (with 14 carcinomas). Eleven of these carcinomas did not recur during follow-up periods that ranged from 3 to 53 months. Three carcinomas recurred at 9, 12, and 35 months, respectively. For 26 carcinomas, the response was less than complete, and alternative therapy was necessary. The carcinomas in patients with a complete response were radiographically occult, were less than 3 cm2 in surface area, and appeared superficial at bronchoscopy. Our experience supports the use of hematoporphyrin derivative phototherapy as an alternative to surgical resection in carefully selected patients.

UR - http://www.scopus.com/inward/record.url?scp=0023088364&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0023088364&partnerID=8YFLogxK

U2 - 10.1016/S0025-6196(12)61520-1

DO - 10.1016/S0025-6196(12)61520-1

M3 - Article

C2 - 3025530

AN - SCOPUS:0023088364

VL - 62

SP - 8

EP - 14

JO - Mayo Clinic Proceedings

JF - Mayo Clinic Proceedings

SN - 0025-6196

IS - 1

ER -