Bronchiolitis: The pathologist's perspective

Daniel W Visscher, Jeffrey L. Myers

Research output: Contribution to journalArticle

82 Citations (Scopus)

Abstract

The term "bronchiolitis" refers to a broad morphologic spectrum of inflammatory events that are centered on small conducting airways. Bronchiolitis may be an isolated pathologic finding, although it is often a secondary consequence of diseases affecting other parts of the conducting apparatus or pulmonary acinus. Divergent causes of bronchiolitis may have similar microscopic findings. Hence, a pathologic diagnosis is nonspecific and not clinically meaningful unless placed in the context of relevant clinical and radiographic findings. Etiologically, most cases of bronchiolitis are infectious in nature or related to smoking. Increasingly, other causes of bronchiolitis have been recognized, including collagen vascular disease, idiopathic inflammatory bowel disease, or toxins/drugs. Many cases are idiopathic. Histologically, most examples of bronchiolitis demonstrate acute inflammation, usually corresponding to viral infection. Other well-defined histologic categories of bronchiolitis include bronchiolitis obliterans, in which there is fibroblast proliferation within airspaces, and follicular bronchiolitis, corresponding to lymphoid hyperplasia with formation of germinal centers. In recent years, several new forms of bronchiolitis have been recognized, including constrictive bronchiolitis, diffuse panbronchiolitis, and airway-centered fibrosis. This article highlights the clinical and pathologic features of these more recently described entities.

Original languageEnglish (US)
Pages (from-to)41-47
Number of pages7
JournalProceedings of the American Thoracic Society
Volume3
Issue number1
DOIs
StatePublished - Mar 2006

Fingerprint

Bronchiolitis
Bronchiolitis Obliterans
Pathologists
Collagen Diseases
Germinal Center
Virus Diseases
Vascular Diseases
Inflammatory Bowel Diseases
Hyperplasia
Fibrosis
Fibroblasts
Smoking
Inflammation
Lung

Keywords

  • Bronchiolitis
  • Lung pathology
  • Pulmonary infection

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Physiology
  • Cell Biology

Cite this

Bronchiolitis : The pathologist's perspective. / Visscher, Daniel W; Myers, Jeffrey L.

In: Proceedings of the American Thoracic Society, Vol. 3, No. 1, 03.2006, p. 41-47.

Research output: Contribution to journalArticle

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