Brief report: Long-term functional engraftment of mesenchymal progenitor cells in a mouse model of accelerated aging

Lakshman Singh, Tracy A. Brennan, Jung Hoon Kim, Kevin P. Egan, Emily A. McMillan, Qijun Chen, Kurt D. Hankenson, Yi Zhang, Stephen G. Emerson, F. Brad Johnson, Robert J. Pignolo

Research output: Contribution to journalArticle

18 Scopus citations

Abstract

Age-related osteoporosis is characterized by a decrease in bone-forming capacity mediated by defects in the number and function of osteoblasts. An important cellular mechanism that may in part explain osteoblast dysfunction that occurs with aging is senescence of mesenchymal progenitor cells (MPCs). In the telomere-based Wrn-/-Terc-/- model of accelerated aging, the osteoporotic phenotype of these mice is also associated with a major decline in MPC differentiation into osteoblasts. To investigate the role of MPC aging as a cell-autonomous mechanism in senile bone loss, transplantation of young wild-type whole bone marrow into Wrn-/-Terc-/- mutants was performed and the ability of engrafted cells to differentiate into cells of the osteoblast lineage was assessed. We found that whole bone marrow transplantation in Wrn-/-Terc-/- mice resulted in functional engraftment of MPCs up to 42 weeks, which was accompanied by a survival advantage as well as delays in microarchitectural features of skeletal aging.

Original languageEnglish (US)
Pages (from-to)607-611
Number of pages5
JournalStem Cells
Volume31
Issue number3
DOIs
StatePublished - Mar 1 2013

Keywords

  • Aging
  • Engraftment
  • Mesenchymal stem cells
  • Osteoporosis
  • Telomere
  • Telomere dysfunction

ASJC Scopus subject areas

  • Molecular Medicine
  • Developmental Biology
  • Cell Biology

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    Singh, L., Brennan, T. A., Kim, J. H., Egan, K. P., McMillan, E. A., Chen, Q., Hankenson, K. D., Zhang, Y., Emerson, S. G., Johnson, F. B., & Pignolo, R. J. (2013). Brief report: Long-term functional engraftment of mesenchymal progenitor cells in a mouse model of accelerated aging. Stem Cells, 31(3), 607-611. https://doi.org/10.1002/stem.1294