Breast tumor metastasis: Analysis via proteomic profiling

Steven Goodison, Virginia Urquidi

Research output: Contribution to journalReview article

7 Citations (Scopus)

Abstract

The ability to predict the metastatic behavior of a patient's cancer, as well as to detect and eradicate such recurrences, remain major clinical challenges in oncology. While many potential molecular biomarkers have been identified and tested previously, none have greatly improved the accuracy of specimen evaluation over routine histopathological criteria and, to date, they predict individual outcomes poorly. The ongoing development of high-throughput proteomic profiling technologies is opening new avenues for the investigation of cancer and, through application in tissue-based studies and animal models, will facilitate the identification of molecular signatures that are associated with breast tumor cell phenotype. The appropriate use of these approaches has the potential to provide efficient biomarkers, and to improve our knowledge of tumor biology. This, in turn, will enable the development of targeted therapeutics aimed at ameliorating the lethal dissemination of breast cancer. In this review, we focus on the accumulating proteomic signatures of breast tumor progression, particularly those that correlate with the occurrence of distant metastases, and discuss some of the expected future developments in the field.

Original languageEnglish (US)
Pages (from-to)457-467
Number of pages11
JournalExpert Review of Proteomics
Volume5
Issue number3
DOIs
StatePublished - Jun 1 2008
Externally publishedYes

Fingerprint

Proteomics
Tumors
Biomarkers
Breast Neoplasms
Neoplasm Metastasis
Neoplasms
Oncology
Identification (control systems)
Animals
Animal Models
Cells
Throughput
Tissue
Technology
Phenotype
Recurrence
Therapeutics

Keywords

  • 2D separation
  • Biomarkers
  • Breast cancer
  • Laser-capture microdissection
  • Molecular prognostics
  • Oncoproteomics
  • Tissue microarray

ASJC Scopus subject areas

  • Biotechnology
  • Genetics
  • Molecular Biology

Cite this

Breast tumor metastasis : Analysis via proteomic profiling. / Goodison, Steven; Urquidi, Virginia.

In: Expert Review of Proteomics, Vol. 5, No. 3, 01.06.2008, p. 457-467.

Research output: Contribution to journalReview article

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