Breast carcinoma in young women

Patricia S. Simmons, Yasmin L. Jayasinghe, Lester E. Wold, L. Joseph Melton

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Objective: To estimate the incidence of breast carcinoma and survival in patients younger than 25 years old, and to describe presenting clinical signs and symptoms of breast cancer in this age group. Methods: A population-based descriptive study and case review in Olmsted County, Minnesota, was conducted using the resources of the Rochester Epidemiology Project. Participants were Olmsted County girls and women younger than 25 years old with histopathologically confirmed breast carcinoma diagnosed between 1935 and 2005. Nonresidents who presented to a medical facility within Olmsted County during this time period were included in some portions of the analysis. Main outcome measures were age-adjusted incidence, 5-year survival, and clinical presentation of breast carcinoma in girls and women younger than 25 years of age. Results: With four breast carcinomas observed in Olmsted County residents over 1,201,539 person-years, the annual age-adjusted incidence of breast cancer in this population was 3.2 per million (95% confidence interval, 0.1-6.2). All four cancers occurred in the 20-to 24-year age group (age-specific incidence, 16.2 per million). Eight additional cases of breast carcinoma were identified in nonresidents. Delay in diagnosis was common. All had at least one feature worrisome for an aggressive neoplasm identified in their clinical history, on physical examination or by imaging. Conclusion: Breast carcinoma in young women is very rare, associated with delayed diagnosis, and usually associated with concerning features requiring biopsy.

Original languageEnglish (US)
Pages (from-to)529-536
Number of pages8
JournalObstetrics and Gynecology
Volume118
Issue number3
DOIs
StatePublished - Sep 2011

Fingerprint

Breast Neoplasms
Incidence
Age Groups
Survival
Delayed Diagnosis
Population
Signs and Symptoms
Physical Examination
Neoplasms
Epidemiology
Outcome Assessment (Health Care)
Confidence Intervals
Biopsy

ASJC Scopus subject areas

  • Obstetrics and Gynecology

Cite this

Simmons, P. S., Jayasinghe, Y. L., Wold, L. E., & Melton, L. J. (2011). Breast carcinoma in young women. Obstetrics and Gynecology, 118(3), 529-536. https://doi.org/10.1097/AOG.0b013e31822a69db

Breast carcinoma in young women. / Simmons, Patricia S.; Jayasinghe, Yasmin L.; Wold, Lester E.; Melton, L. Joseph.

In: Obstetrics and Gynecology, Vol. 118, No. 3, 09.2011, p. 529-536.

Research output: Contribution to journalArticle

Simmons, PS, Jayasinghe, YL, Wold, LE & Melton, LJ 2011, 'Breast carcinoma in young women', Obstetrics and Gynecology, vol. 118, no. 3, pp. 529-536. https://doi.org/10.1097/AOG.0b013e31822a69db
Simmons PS, Jayasinghe YL, Wold LE, Melton LJ. Breast carcinoma in young women. Obstetrics and Gynecology. 2011 Sep;118(3):529-536. https://doi.org/10.1097/AOG.0b013e31822a69db
Simmons, Patricia S. ; Jayasinghe, Yasmin L. ; Wold, Lester E. ; Melton, L. Joseph. / Breast carcinoma in young women. In: Obstetrics and Gynecology. 2011 ; Vol. 118, No. 3. pp. 529-536.
@article{c0fe8b5bd3c24c388959434976d4f876,
title = "Breast carcinoma in young women",
abstract = "Objective: To estimate the incidence of breast carcinoma and survival in patients younger than 25 years old, and to describe presenting clinical signs and symptoms of breast cancer in this age group. Methods: A population-based descriptive study and case review in Olmsted County, Minnesota, was conducted using the resources of the Rochester Epidemiology Project. Participants were Olmsted County girls and women younger than 25 years old with histopathologically confirmed breast carcinoma diagnosed between 1935 and 2005. Nonresidents who presented to a medical facility within Olmsted County during this time period were included in some portions of the analysis. Main outcome measures were age-adjusted incidence, 5-year survival, and clinical presentation of breast carcinoma in girls and women younger than 25 years of age. Results: With four breast carcinomas observed in Olmsted County residents over 1,201,539 person-years, the annual age-adjusted incidence of breast cancer in this population was 3.2 per million (95{\%} confidence interval, 0.1-6.2). All four cancers occurred in the 20-to 24-year age group (age-specific incidence, 16.2 per million). Eight additional cases of breast carcinoma were identified in nonresidents. Delay in diagnosis was common. All had at least one feature worrisome for an aggressive neoplasm identified in their clinical history, on physical examination or by imaging. Conclusion: Breast carcinoma in young women is very rare, associated with delayed diagnosis, and usually associated with concerning features requiring biopsy.",
author = "Simmons, {Patricia S.} and Jayasinghe, {Yasmin L.} and Wold, {Lester E.} and Melton, {L. Joseph}",
year = "2011",
month = "9",
doi = "10.1097/AOG.0b013e31822a69db",
language = "English (US)",
volume = "118",
pages = "529--536",
journal = "Obstetrics and Gynecology",
issn = "0029-7844",
publisher = "Lippincott Williams and Wilkins",
number = "3",

}

TY - JOUR

T1 - Breast carcinoma in young women

AU - Simmons, Patricia S.

AU - Jayasinghe, Yasmin L.

AU - Wold, Lester E.

AU - Melton, L. Joseph

PY - 2011/9

Y1 - 2011/9

N2 - Objective: To estimate the incidence of breast carcinoma and survival in patients younger than 25 years old, and to describe presenting clinical signs and symptoms of breast cancer in this age group. Methods: A population-based descriptive study and case review in Olmsted County, Minnesota, was conducted using the resources of the Rochester Epidemiology Project. Participants were Olmsted County girls and women younger than 25 years old with histopathologically confirmed breast carcinoma diagnosed between 1935 and 2005. Nonresidents who presented to a medical facility within Olmsted County during this time period were included in some portions of the analysis. Main outcome measures were age-adjusted incidence, 5-year survival, and clinical presentation of breast carcinoma in girls and women younger than 25 years of age. Results: With four breast carcinomas observed in Olmsted County residents over 1,201,539 person-years, the annual age-adjusted incidence of breast cancer in this population was 3.2 per million (95% confidence interval, 0.1-6.2). All four cancers occurred in the 20-to 24-year age group (age-specific incidence, 16.2 per million). Eight additional cases of breast carcinoma were identified in nonresidents. Delay in diagnosis was common. All had at least one feature worrisome for an aggressive neoplasm identified in their clinical history, on physical examination or by imaging. Conclusion: Breast carcinoma in young women is very rare, associated with delayed diagnosis, and usually associated with concerning features requiring biopsy.

AB - Objective: To estimate the incidence of breast carcinoma and survival in patients younger than 25 years old, and to describe presenting clinical signs and symptoms of breast cancer in this age group. Methods: A population-based descriptive study and case review in Olmsted County, Minnesota, was conducted using the resources of the Rochester Epidemiology Project. Participants were Olmsted County girls and women younger than 25 years old with histopathologically confirmed breast carcinoma diagnosed between 1935 and 2005. Nonresidents who presented to a medical facility within Olmsted County during this time period were included in some portions of the analysis. Main outcome measures were age-adjusted incidence, 5-year survival, and clinical presentation of breast carcinoma in girls and women younger than 25 years of age. Results: With four breast carcinomas observed in Olmsted County residents over 1,201,539 person-years, the annual age-adjusted incidence of breast cancer in this population was 3.2 per million (95% confidence interval, 0.1-6.2). All four cancers occurred in the 20-to 24-year age group (age-specific incidence, 16.2 per million). Eight additional cases of breast carcinoma were identified in nonresidents. Delay in diagnosis was common. All had at least one feature worrisome for an aggressive neoplasm identified in their clinical history, on physical examination or by imaging. Conclusion: Breast carcinoma in young women is very rare, associated with delayed diagnosis, and usually associated with concerning features requiring biopsy.

UR - http://www.scopus.com/inward/record.url?scp=80052176396&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=80052176396&partnerID=8YFLogxK

U2 - 10.1097/AOG.0b013e31822a69db

DO - 10.1097/AOG.0b013e31822a69db

M3 - Article

VL - 118

SP - 529

EP - 536

JO - Obstetrics and Gynecology

JF - Obstetrics and Gynecology

SN - 0029-7844

IS - 3

ER -