Breast carcinoma associated with necrotic granulomas in axillary lymph nodes

Sanjeev M Sethi, Darryl Carter

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

From a series of 100 consecutive breast carcinomas with axillary lymph node metastases, two cases of necrotic granulomas in the nodes are presented. Lymph nodes in each case were characterized by areas of necrosis surrounded by a palisade of cells resembling histiocytes as seen in a rheumatoid nodule. Although the initial impression was that of a reactive granuloma, when immunostained for keratin and EMA, the areas of necrosis showed positive staining for keratin and EMA in a cytoplasmic pattern. The surrounding palisade of cells stained with histiocyte markers, while the necrotic area itself was negative. Staining for both estrogen and progesterone markers was also negative. Staining of nine lymph nodes with caseating granulomas not associated with carcinoma with the same panel of antibodies revealed no staining except for irregular, noncellular staining with EMA. This pattern of necrosis in axillary lymph nodes from two cases of breast carcinoma was interpreted as evidence of necrotic metastatic tumor cells. Necrosis in axillary lymph nodes associated with invasive breast cancer should arouse suspicion for metastasis.

Original languageEnglish (US)
Pages (from-to)370-376
Number of pages7
JournalAnnals of Diagnostic Pathology
Volume2
Issue number6
StatePublished - 1998
Externally publishedYes

Fingerprint

Granuloma
Lymph Nodes
Staining and Labeling
Breast Neoplasms
Necrosis
Histiocytes
Keratins
Rheumatoid Nodule
Neoplasm Metastasis
Progesterone
Estrogens
Carcinoma
Antibodies
Neoplasms

Keywords

  • Axillary lymph nodes
  • Breast carcinoma
  • EMA
  • Immunohistochemistry
  • Keratin
  • Necrotizing granuloma

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Breast carcinoma associated with necrotic granulomas in axillary lymph nodes. / Sethi, Sanjeev M; Carter, Darryl.

In: Annals of Diagnostic Pathology, Vol. 2, No. 6, 1998, p. 370-376.

Research output: Contribution to journalArticle

@article{924437d97b334f868d1feac81c6149fc,
title = "Breast carcinoma associated with necrotic granulomas in axillary lymph nodes",
abstract = "From a series of 100 consecutive breast carcinomas with axillary lymph node metastases, two cases of necrotic granulomas in the nodes are presented. Lymph nodes in each case were characterized by areas of necrosis surrounded by a palisade of cells resembling histiocytes as seen in a rheumatoid nodule. Although the initial impression was that of a reactive granuloma, when immunostained for keratin and EMA, the areas of necrosis showed positive staining for keratin and EMA in a cytoplasmic pattern. The surrounding palisade of cells stained with histiocyte markers, while the necrotic area itself was negative. Staining for both estrogen and progesterone markers was also negative. Staining of nine lymph nodes with caseating granulomas not associated with carcinoma with the same panel of antibodies revealed no staining except for irregular, noncellular staining with EMA. This pattern of necrosis in axillary lymph nodes from two cases of breast carcinoma was interpreted as evidence of necrotic metastatic tumor cells. Necrosis in axillary lymph nodes associated with invasive breast cancer should arouse suspicion for metastasis.",
keywords = "Axillary lymph nodes, Breast carcinoma, EMA, Immunohistochemistry, Keratin, Necrotizing granuloma",
author = "Sethi, {Sanjeev M} and Darryl Carter",
year = "1998",
language = "English (US)",
volume = "2",
pages = "370--376",
journal = "Annals of Diagnostic Pathology",
issn = "1092-9134",
publisher = "W.B. Saunders Ltd",
number = "6",

}

TY - JOUR

T1 - Breast carcinoma associated with necrotic granulomas in axillary lymph nodes

AU - Sethi, Sanjeev M

AU - Carter, Darryl

PY - 1998

Y1 - 1998

N2 - From a series of 100 consecutive breast carcinomas with axillary lymph node metastases, two cases of necrotic granulomas in the nodes are presented. Lymph nodes in each case were characterized by areas of necrosis surrounded by a palisade of cells resembling histiocytes as seen in a rheumatoid nodule. Although the initial impression was that of a reactive granuloma, when immunostained for keratin and EMA, the areas of necrosis showed positive staining for keratin and EMA in a cytoplasmic pattern. The surrounding palisade of cells stained with histiocyte markers, while the necrotic area itself was negative. Staining for both estrogen and progesterone markers was also negative. Staining of nine lymph nodes with caseating granulomas not associated with carcinoma with the same panel of antibodies revealed no staining except for irregular, noncellular staining with EMA. This pattern of necrosis in axillary lymph nodes from two cases of breast carcinoma was interpreted as evidence of necrotic metastatic tumor cells. Necrosis in axillary lymph nodes associated with invasive breast cancer should arouse suspicion for metastasis.

AB - From a series of 100 consecutive breast carcinomas with axillary lymph node metastases, two cases of necrotic granulomas in the nodes are presented. Lymph nodes in each case were characterized by areas of necrosis surrounded by a palisade of cells resembling histiocytes as seen in a rheumatoid nodule. Although the initial impression was that of a reactive granuloma, when immunostained for keratin and EMA, the areas of necrosis showed positive staining for keratin and EMA in a cytoplasmic pattern. The surrounding palisade of cells stained with histiocyte markers, while the necrotic area itself was negative. Staining for both estrogen and progesterone markers was also negative. Staining of nine lymph nodes with caseating granulomas not associated with carcinoma with the same panel of antibodies revealed no staining except for irregular, noncellular staining with EMA. This pattern of necrosis in axillary lymph nodes from two cases of breast carcinoma was interpreted as evidence of necrotic metastatic tumor cells. Necrosis in axillary lymph nodes associated with invasive breast cancer should arouse suspicion for metastasis.

KW - Axillary lymph nodes

KW - Breast carcinoma

KW - EMA

KW - Immunohistochemistry

KW - Keratin

KW - Necrotizing granuloma

UR - http://www.scopus.com/inward/record.url?scp=0032241522&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0032241522&partnerID=8YFLogxK

M3 - Article

VL - 2

SP - 370

EP - 376

JO - Annals of Diagnostic Pathology

JF - Annals of Diagnostic Pathology

SN - 1092-9134

IS - 6

ER -