Breast cancer survivors and vitamin D: A review

Stephanie L. Hines, H. Keels S. Jorn, Kristine M. Thompson, Jan M. Larson

Research output: Contribution to journalReview article

32 Scopus citations

Abstract

Recent evidence has suggested a role for vitamin D in breast cancer prevention and survival. Studies have reported an inverse relation between vitamin D intake and the risk of breast cancer, improvements in survival after a diagnosis of breast cancer in women with higher levels of vitamin D, and vitamin D insufficiency in up to 75% of women with breast cancer. Preclinical data have indicated that vitamin D affects up to 200 genes that influence cellular proliferation, apoptosis, angiogenesis, terminal differentiation of normal and cancer cells, and macrophage function. Vitamin D receptors have been found in up to 80% of breast cancers, and vitamin D receptor polymorphisms have been associated with differences in survival. Although ongoing studies have investigated a possible link between adequate levels of vitamin D and improved cancer prognosis, breast cancer survivors may derive additional, non-cancer-related benefits from adequate vitamin D levels, including improvements in bone mineral density, quality of life, and mood. Maintaining adequate vitamin D stores is recommended for breast cancer survivors throughout their lifetime.

Original languageEnglish (US)
Pages (from-to)255-262
Number of pages8
JournalNutrition
Volume26
Issue number3
DOIs
StatePublished - Mar 1 2010

Keywords

  • Breast cancer
  • Cancer survivor
  • Vitamin D
  • Vitamin D insufficiency

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Nutrition and Dietetics

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    Hines, S. L., Jorn, H. K. S., Thompson, K. M., & Larson, J. M. (2010). Breast cancer survivors and vitamin D: A review. Nutrition, 26(3), 255-262. https://doi.org/10.1016/j.nut.2009.08.020