BRCA proteins and DNA damage checkpoints

Zhenkun Lou, Junjie Chen

Research output: Contribution to journalReview article

9 Scopus citations

Abstract

BRCA1 and BRCA2 are frequently mutated in breast cancer patients, responsible for the majority cases of familial breast cancer. Through genetic and biochemical analysis, the function of BRCA1 and BRCA2 is emerging. This review examines recent progresses in understanding the roles of BRCA proteins in DNA damage checkpoint control and how they are regulated in response to DNA damage.

Original languageEnglish (US)
Pages (from-to)s718-s721
JournalFrontiers in Bioscience
Volume8
Issue numberSUPPL.
StatePublished - Jan 1 2003

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Keywords

  • BRCA1
  • BRCA2
  • Checkpoint Control
  • DNA damage
  • Review

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)

Cite this

Lou, Z., & Chen, J. (2003). BRCA proteins and DNA damage checkpoints. Frontiers in Bioscience, 8(SUPPL.), s718-s721.