Abstract
BRCA1 and BRCA2 are frequently mutated in breast cancer patients, responsible for the majority cases of familial breast cancer. Through genetic and biochemical analysis, the function of BRCA1 and BRCA2 is emerging. This review examines recent progresses in understanding the roles of BRCA proteins in DNA damage checkpoint control and how they are regulated in response to DNA damage.
| Original language | English (US) |
|---|---|
| Pages (from-to) | s718-s721 |
| Journal | Frontiers in Bioscience |
| Volume | 8 |
| Issue number | SUPPL. |
| State | Published - 2003 |
Keywords
- BRCA1
- BRCA2
- Checkpoint Control
- DNA damage
- Review
ASJC Scopus subject areas
- General Biochemistry, Genetics and Molecular Biology
- General Immunology and Microbiology