BRCA-associated cancers: Role of imaging in screening, diagnosis, and management

Michelle V. Lee, Venkata S. Katabathina, Michyla L. Bowerson, Marina I. Mityul, Anup S. Shetty, Khaled M. Elsayes, Aparna Balachandran, Priya R. Bhosale, Ann E. McCullough, Christine O. Menias

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Harmful mutations of the BRCA tumor suppressor genes result in a greater lifetime risk for malignancy—breast and ovarian cancers in particular. An increased risk for male breast, fallopian tube, primary peritoneal, pancreatic, prostate, and colon cancers also has been reported. The BRCA gene is inherited in an autosomal dominant pattern and tends to be highly penetrant; thus, there is an increased incidence of these cancers in affected families. Compared with sporadic tumors, BRCA-associated malignancies have unique manifestations, clinical features, and pathologic profiles. Manifestation at an early patient age, high-grade tumors, and an aggressive clinical course are common features of BRCA-associated malignancies. Understanding the behavior of these cancers aids in identification of affected individuals and families, who can then make informed decisions regarding their future health. Enhanced screening, prophylactic surgery, and chemoprevention are options for managing cancer risk factors in these individuals. Imaging has an important role in the screening, evaluation, staging, and follow-up of BRCA associated malignancies. Supplemental screening of BRCA mutation carriers often begins at an early age and is critical for early and accurate cancer diagnoses. The authors review the etiopathogenesis and imaging features of BRCA-associated malignancies, the importance of a multidisciplinary approach to determining the diagnosis, and the treatment of patients who have these mutations to improve their outcomes.

Original languageEnglish (US)
Pages (from-to)1005-1023
Number of pages19
JournalRadiographics
Volume37
Issue number4
DOIs
StatePublished - Jul 1 2017

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Neoplasms
Mutation
Fallopian Tubes
Chemoprevention
Tumor Suppressor Genes
Pancreatic Neoplasms
Early Detection of Cancer
Ovarian Neoplasms
Colonic Neoplasms
Prostatic Neoplasms
Breast
Incidence
Health
Genes
Therapeutics

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

Lee, M. V., Katabathina, V. S., Bowerson, M. L., Mityul, M. I., Shetty, A. S., Elsayes, K. M., ... Menias, C. O. (2017). BRCA-associated cancers: Role of imaging in screening, diagnosis, and management. Radiographics, 37(4), 1005-1023. https://doi.org/10.1148/rg.2017160144

BRCA-associated cancers : Role of imaging in screening, diagnosis, and management. / Lee, Michelle V.; Katabathina, Venkata S.; Bowerson, Michyla L.; Mityul, Marina I.; Shetty, Anup S.; Elsayes, Khaled M.; Balachandran, Aparna; Bhosale, Priya R.; McCullough, Ann E.; Menias, Christine O.

In: Radiographics, Vol. 37, No. 4, 01.07.2017, p. 1005-1023.

Research output: Contribution to journalArticle

Lee, MV, Katabathina, VS, Bowerson, ML, Mityul, MI, Shetty, AS, Elsayes, KM, Balachandran, A, Bhosale, PR, McCullough, AE & Menias, CO 2017, 'BRCA-associated cancers: Role of imaging in screening, diagnosis, and management', Radiographics, vol. 37, no. 4, pp. 1005-1023. https://doi.org/10.1148/rg.2017160144
Lee MV, Katabathina VS, Bowerson ML, Mityul MI, Shetty AS, Elsayes KM et al. BRCA-associated cancers: Role of imaging in screening, diagnosis, and management. Radiographics. 2017 Jul 1;37(4):1005-1023. https://doi.org/10.1148/rg.2017160144
Lee, Michelle V. ; Katabathina, Venkata S. ; Bowerson, Michyla L. ; Mityul, Marina I. ; Shetty, Anup S. ; Elsayes, Khaled M. ; Balachandran, Aparna ; Bhosale, Priya R. ; McCullough, Ann E. ; Menias, Christine O. / BRCA-associated cancers : Role of imaging in screening, diagnosis, and management. In: Radiographics. 2017 ; Vol. 37, No. 4. pp. 1005-1023.
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