Branch architecture of the fly larval abdominal serotonergic neurons

John Chen, Barry G. Condron

Research output: Contribution to journalArticle

26 Scopus citations

Abstract

In the metazoan central nervous system (CNS), serotonergic neurons send projections throughout the synaptic neuropil. Little is known about the rules that govern these widespread neuromodulatory branching patterns. In this study, we utilize the Drosophila as a model to examine serotonergic branching. Using single cell GFP labeling we show that within each segment of the Drosophila ventral nerve cord (VNC), each of two serotonergic neurons tiles distinct innervation patterns in the contralateral neuropil. In addition, branches extend only a short distance from the target segment. Through ablation-mediated isolation of serotonergic cells, we demonstrate that the distinct areas of innervation are not maintained through competition between neighboring like-serotonergic neurites. Furthermore, the basic branching pattern of serotonergic neurons within the neuropil remains unchanged despite alterations of initial axonal trajectories.

Original languageEnglish (US)
Pages (from-to)30-38
Number of pages9
JournalDevelopmental Biology
Volume320
Issue number1
DOIs
StatePublished - Aug 1 2008

Keywords

  • Axon guidance
  • Branch morphology
  • CNS development
  • Competition
  • Neurite formation
  • Neurotransmitter
  • Serotonin
  • Tiling

ASJC Scopus subject areas

  • Molecular Biology
  • Developmental Biology
  • Cell Biology

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