Brainstem 1H Nuclear Magnetic Resonance (NMR) spectroscopy: Marker of demyelination and repair in spinal cord

Aleksandar Denic; Allan Bieber; Arthur Warrington; Prasanna K. Mishra; Slobodan Macura; Moses Rodriguez

doi:10.1002/ana.21758

Brainstem ¹H Nuclear Magnetic Resonance (NMR) spectroscopy: Marker of demyelination and repair in spinal cord

Aleksandar Denic, Allan Bieber, Arthur Warrington, Prasanna K. Mishra, Slobodan Macura, Moses Rodriguez

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Abstract

Measuring in vivo spinal cord injury and repair remains elusive. Using magnetic resonance spectroscopy (MRS) we examined brainstem N-acetyl-aspartate (NAA) as a surrogate for spinal cord injury in two mouse strains with different reparative phenotypes following virus-induced demyelination. Swiss Jim Lambert (SJL) and Friend Virus B (FVB) mice progressively demyelinate with axonal loss. FVB mice demyelinate similarly but eventually remyelinate coincident with functional recovery. Brainstem NAA levels drop in both but recover in FVB mice. Chronically infected SJL mice lost 30.5% of spinal cord axons compared to FVB mice (7.3%). In remyelination-enhancing or axon-preserving clinical trials, brainstem MRS may be a viable endpoint to represent overall spinal cord dysfunction.

Original language	English (US)
Pages (from-to)	559-564
Number of pages	6
Journal	Annals of neurology
Volume	66
Issue number	4
DOIs	https://doi.org/10.1002/ana.21758
State	Published - 2009

ASJC Scopus subject areas

Neurology
Clinical Neurology

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abstract = "Measuring in vivo spinal cord injury and repair remains elusive. Using magnetic resonance spectroscopy (MRS) we examined brainstem N-acetyl-aspartate (NAA) as a surrogate for spinal cord injury in two mouse strains with different reparative phenotypes following virus-induced demyelination. Swiss Jim Lambert (SJL) and Friend Virus B (FVB) mice progressively demyelinate with axonal loss. FVB mice demyelinate similarly but eventually remyelinate coincident with functional recovery. Brainstem NAA levels drop in both but recover in FVB mice. Chronically infected SJL mice lost 30.5% of spinal cord axons compared to FVB mice (7.3%). In remyelination-enhancing or axon-preserving clinical trials, brainstem MRS may be a viable endpoint to represent overall spinal cord dysfunction.",

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Brainstem ¹H Nuclear Magnetic Resonance (NMR) spectroscopy: Marker of demyelination and repair in spinal cord

Abstract

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