Brainstem 1H Nuclear Magnetic Resonance (NMR) spectroscopy: Marker of demyelination and repair in spinal cord

Aleksandar Denic, Allan Bieber, Arthur Warrington, Prasanna K. Mishra, Slobodan Macura, Moses Rodriguez

Research output: Contribution to journalArticlepeer-review

16 Scopus citations

Abstract

Measuring in vivo spinal cord injury and repair remains elusive. Using magnetic resonance spectroscopy (MRS) we examined brainstem N-acetyl-aspartate (NAA) as a surrogate for spinal cord injury in two mouse strains with different reparative phenotypes following virus-induced demyelination. Swiss Jim Lambert (SJL) and Friend Virus B (FVB) mice progressively demyelinate with axonal loss. FVB mice demyelinate similarly but eventually remyelinate coincident with functional recovery. Brainstem NAA levels drop in both but recover in FVB mice. Chronically infected SJL mice lost 30.5% of spinal cord axons compared to FVB mice (7.3%). In remyelination-enhancing or axon-preserving clinical trials, brainstem MRS may be a viable endpoint to represent overall spinal cord dysfunction.

Original languageEnglish (US)
Pages (from-to)559-564
Number of pages6
JournalAnnals of neurology
Volume66
Issue number4
DOIs
StatePublished - 2009

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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