Brain tumor related-epilepsy

Eric D. Goldstein, Anteneh M. Feyissa

Research output: Contribution to journalReview articlepeer-review

4 Scopus citations

Abstract

Introduction: Gliomas are commonly associated with the development of epilepsy; in some cases the two conditions share common pathogenic mechanisms and may influence each other. Brain tumor related-epilepsy (BTRE) complicates the clinical management of gliomas and can substantially affect daily life. State of the art: The incidence of seizures is high in patients with slow growing tumors located in the frontotemporal regions. However, recent studies suggest that epileptogenesis may be more associated with tumor molecular genetic markers than tumor grade or location. Although the exact mechanism of epileptogenesis in glioma is incompletely understood, glutamate-induced excitotoxicity and disruption of intracellular communication have garnered the most attention. Clinical management: Management of BTRE requires a multidisciplinary approach involving the use of antiepileptic drugs (AEDs), surgery aided by electrocorticography, and adjuvant chemoradiation. Future directions: Insight into the mechanisms of glioma growth and epileptogenesis is essential to identify new treatment targets and to develop effective treatment for both conditions. Selecting AEDs tailored to act against known tumor molecular markers involved in the epileptogenesis could enhance treatment value and help inform individualized medicine in BRTE.

Original languageEnglish (US)
Pages (from-to)436-447
Number of pages12
JournalNeurologia i neurochirurgia polska
Volume52
Issue number4
DOIs
StatePublished - Aug 2018

Keywords

  • Antiepileptic drugs
  • Epileptogensis
  • Glioma
  • IDH1 mutation
  • Tumors markers

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology

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