Brain tumor related-epilepsy

Eric D. Goldstein; Anteneh M. Feyissa

doi:10.1016/j.pjnns.2018.06.001

Brain tumor related-epilepsy

Eric D. Goldstein, Anteneh M. Feyissa

Neurology

Research output: Contribution to journal › Review article › peer-review

7 Scopus citations

Abstract

Introduction: Gliomas are commonly associated with the development of epilepsy; in some cases the two conditions share common pathogenic mechanisms and may influence each other. Brain tumor related-epilepsy (BTRE) complicates the clinical management of gliomas and can substantially affect daily life. State of the art: The incidence of seizures is high in patients with slow growing tumors located in the frontotemporal regions. However, recent studies suggest that epileptogenesis may be more associated with tumor molecular genetic markers than tumor grade or location. Although the exact mechanism of epileptogenesis in glioma is incompletely understood, glutamate-induced excitotoxicity and disruption of intracellular communication have garnered the most attention. Clinical management: Management of BTRE requires a multidisciplinary approach involving the use of antiepileptic drugs (AEDs), surgery aided by electrocorticography, and adjuvant chemoradiation. Future directions: Insight into the mechanisms of glioma growth and epileptogenesis is essential to identify new treatment targets and to develop effective treatment for both conditions. Selecting AEDs tailored to act against known tumor molecular markers involved in the epileptogenesis could enhance treatment value and help inform individualized medicine in BRTE.

Original language	English (US)
Pages (from-to)	436-447
Number of pages	12
Journal	Neurologia i neurochirurgia polska
Volume	52
Issue number	4
DOIs	https://doi.org/10.1016/j.pjnns.2018.06.001
State	Published - Aug 2018

Keywords

Antiepileptic drugs
Epileptogensis
Glioma
IDH1 mutation
Tumors markers

ASJC Scopus subject areas

Surgery
Clinical Neurology

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10.1016/j.pjnns.2018.06.001

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title = "Brain tumor related-epilepsy",

abstract = "Introduction: Gliomas are commonly associated with the development of epilepsy; in some cases the two conditions share common pathogenic mechanisms and may influence each other. Brain tumor related-epilepsy (BTRE) complicates the clinical management of gliomas and can substantially affect daily life. State of the art: The incidence of seizures is high in patients with slow growing tumors located in the frontotemporal regions. However, recent studies suggest that epileptogenesis may be more associated with tumor molecular genetic markers than tumor grade or location. Although the exact mechanism of epileptogenesis in glioma is incompletely understood, glutamate-induced excitotoxicity and disruption of intracellular communication have garnered the most attention. Clinical management: Management of BTRE requires a multidisciplinary approach involving the use of antiepileptic drugs (AEDs), surgery aided by electrocorticography, and adjuvant chemoradiation. Future directions: Insight into the mechanisms of glioma growth and epileptogenesis is essential to identify new treatment targets and to develop effective treatment for both conditions. Selecting AEDs tailored to act against known tumor molecular markers involved in the epileptogenesis could enhance treatment value and help inform individualized medicine in BRTE.",

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author = "Goldstein, {Eric D.} and Feyissa, {Anteneh M.}",

note = "Funding Information: Dr. Feyissa is supported by the Accelerator for Clinicians Engaged in Research and Neuroscience Focused Research Team Programs, Mayo Clinic. Dr. Feyissa is also a recipient of the American Epilepsy Society (AES) Research and Training Fellowship for Clinicians award (2018). Publisher Copyright: {\textcopyright} 2018 Copyright: Copyright 2019 Elsevier B.V., All rights reserved.",

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N2 - Introduction: Gliomas are commonly associated with the development of epilepsy; in some cases the two conditions share common pathogenic mechanisms and may influence each other. Brain tumor related-epilepsy (BTRE) complicates the clinical management of gliomas and can substantially affect daily life. State of the art: The incidence of seizures is high in patients with slow growing tumors located in the frontotemporal regions. However, recent studies suggest that epileptogenesis may be more associated with tumor molecular genetic markers than tumor grade or location. Although the exact mechanism of epileptogenesis in glioma is incompletely understood, glutamate-induced excitotoxicity and disruption of intracellular communication have garnered the most attention. Clinical management: Management of BTRE requires a multidisciplinary approach involving the use of antiepileptic drugs (AEDs), surgery aided by electrocorticography, and adjuvant chemoradiation. Future directions: Insight into the mechanisms of glioma growth and epileptogenesis is essential to identify new treatment targets and to develop effective treatment for both conditions. Selecting AEDs tailored to act against known tumor molecular markers involved in the epileptogenesis could enhance treatment value and help inform individualized medicine in BRTE.

AB - Introduction: Gliomas are commonly associated with the development of epilepsy; in some cases the two conditions share common pathogenic mechanisms and may influence each other. Brain tumor related-epilepsy (BTRE) complicates the clinical management of gliomas and can substantially affect daily life. State of the art: The incidence of seizures is high in patients with slow growing tumors located in the frontotemporal regions. However, recent studies suggest that epileptogenesis may be more associated with tumor molecular genetic markers than tumor grade or location. Although the exact mechanism of epileptogenesis in glioma is incompletely understood, glutamate-induced excitotoxicity and disruption of intracellular communication have garnered the most attention. Clinical management: Management of BTRE requires a multidisciplinary approach involving the use of antiepileptic drugs (AEDs), surgery aided by electrocorticography, and adjuvant chemoradiation. Future directions: Insight into the mechanisms of glioma growth and epileptogenesis is essential to identify new treatment targets and to develop effective treatment for both conditions. Selecting AEDs tailored to act against known tumor molecular markers involved in the epileptogenesis could enhance treatment value and help inform individualized medicine in BRTE.

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Brain tumor related-epilepsy

Abstract

Keywords

ASJC Scopus subject areas

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