Brain tau deposition linked to systemic causes of death in normal elderly

Keith Anthony Josephs, Nirubol Tosakulwong, Stephen D. Weigand, Melissa E Murray, Jennifer Lynn Whitwell, Joseph E Parisi, Dennis W Dickson, Ronald Carl Petersen

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

The relationship between causes of death and 4 major neurodegenerative brain proteins (beta-amyloid, tau, alpha-synuclein, and the TAR DNA-binding protein of 43 kDa (TDP-43) were assessed in 94 cognitively normal elderly participants that died without a neurodegenerative disease. There was an association between tau and causes of death (p = 0.01). Tau in the brain was associated with a reduced likelihood of dying from systemic cancers (p = 0.046), and with an increased likelihood of dying from pulmonary (p = 0.03) and gastrointestinal (p = 0.049) diseases. There were no associations between beta-amyloid, alpha-synuclein, or TDP-43 and causes of death. Tau deposition in the brain may have a relationship with systemic causes of death, including cancer, in the cognitively normal elderly.

Original languageEnglish (US)
Pages (from-to)163-166
Number of pages4
JournalNeurobiology of Aging
Volume50
DOIs
StatePublished - Feb 1 2017

Fingerprint

Cause of Death
alpha-Synuclein
DNA-Binding Proteins
Brain
Amyloid beta-Peptides
Amyloid
Neurodegenerative Diseases
Neoplasms
Lung

Keywords

  • Cancer
  • Gastrointestinal disease
  • Mortality
  • Normal aging
  • Pulmonary disease
  • Tau

ASJC Scopus subject areas

  • Neuroscience(all)
  • Aging
  • Developmental Biology
  • Geriatrics and Gerontology
  • Clinical Neurology

Cite this

Brain tau deposition linked to systemic causes of death in normal elderly. / Josephs, Keith Anthony; Tosakulwong, Nirubol; Weigand, Stephen D.; Murray, Melissa E; Whitwell, Jennifer Lynn; Parisi, Joseph E; Dickson, Dennis W; Petersen, Ronald Carl.

In: Neurobiology of Aging, Vol. 50, 01.02.2017, p. 163-166.

Research output: Contribution to journalArticle

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