TY - JOUR
T1 - Brain structure and cerebrovascular risk in cognitively impaired patients
T2 - Shanghai community brain health initiative-pilot phase
AU - He, Jing
AU - Iosif, Ana Maria
AU - Lee, Dong Young
AU - Martinez, Oliver
AU - Chu, Shuguang
AU - Carmichael, Owen
AU - Mortimer, James A.
AU - Zhao, Qianhua
AU - Ding, Ding
AU - Guo, Qihao
AU - Galasko, Douglas
AU - Salmon, David P.
AU - Dai, Qi
AU - Wu, Yougui
AU - Petersen, Ronald C.
AU - Hong, Zhen
AU - Borenstein, Amy R.
AU - DeCarli, Charles
PY - 2010/10
Y1 - 2010/10
N2 - Objective: To investigate the associations among brain morphologic changes as seen on magnetic resonance imaging (MRI), cerebrovascular risk (CVR), and clinical diagnosis and cognition in elderly patients with mild cognitive impairment and dementia living in urban Shanghai. Design: Cross-sectional study performed from May 1, 2007, to November 31, 2008. Setting: Memory Disorders Clinic of the Huashan Hospital and the Shanghai community. Participants: Ninety-six older people: 32 with normal cognition (NC), 30 with amnestic mild cognitive impairment (aMCI), and 34 with dementia. Main Outcome Measures: For each patient, we administered a neurologic and physical examination, neuropsychological evaluation, and brain MRI and genotyped the apolipoprotein E-ε4 (APOE-ε4) gene. The volumes determined by MRI were assessed using a semiautomatic method. Results: Brain volume was significantly smaller in the dementia patients compared with the NC (P < .001) and a MCI patients (P = .04). Hippocampal volume (HV) was lower and white matter hyperintensity (WMH) volume was higher in those with aMCI (HV: P = .03; WMH volume: P = .04) and dementia (HV: P < .001; WMH volume: P = .002) compared with NC participants. The presence of APOE-ε4 was significantly associated with reduced HV (P = .02). Systolic blood pressure was positively associated with CVR score (P = .04); diastolic blood pressure (P = .02) and CVR score (P = .04) were positively associated with WMH volume. The WMH volume (P = .03) and CVR score (P = .03) were higher among dementia patients compared with NC participants. Conclusions: Brain structure changes seen on MRI were significantly associated with clinical diagnosis. In addition, blood pressure was highly associated with CVR score and WMH volume. These results suggest that MRI is a valuable measure of brain injury in a Chinese cohort and can serve to assess the effects of various degenerative and cerebrovascular diseases.
AB - Objective: To investigate the associations among brain morphologic changes as seen on magnetic resonance imaging (MRI), cerebrovascular risk (CVR), and clinical diagnosis and cognition in elderly patients with mild cognitive impairment and dementia living in urban Shanghai. Design: Cross-sectional study performed from May 1, 2007, to November 31, 2008. Setting: Memory Disorders Clinic of the Huashan Hospital and the Shanghai community. Participants: Ninety-six older people: 32 with normal cognition (NC), 30 with amnestic mild cognitive impairment (aMCI), and 34 with dementia. Main Outcome Measures: For each patient, we administered a neurologic and physical examination, neuropsychological evaluation, and brain MRI and genotyped the apolipoprotein E-ε4 (APOE-ε4) gene. The volumes determined by MRI were assessed using a semiautomatic method. Results: Brain volume was significantly smaller in the dementia patients compared with the NC (P < .001) and a MCI patients (P = .04). Hippocampal volume (HV) was lower and white matter hyperintensity (WMH) volume was higher in those with aMCI (HV: P = .03; WMH volume: P = .04) and dementia (HV: P < .001; WMH volume: P = .002) compared with NC participants. The presence of APOE-ε4 was significantly associated with reduced HV (P = .02). Systolic blood pressure was positively associated with CVR score (P = .04); diastolic blood pressure (P = .02) and CVR score (P = .04) were positively associated with WMH volume. The WMH volume (P = .03) and CVR score (P = .03) were higher among dementia patients compared with NC participants. Conclusions: Brain structure changes seen on MRI were significantly associated with clinical diagnosis. In addition, blood pressure was highly associated with CVR score and WMH volume. These results suggest that MRI is a valuable measure of brain injury in a Chinese cohort and can serve to assess the effects of various degenerative and cerebrovascular diseases.
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U2 - 10.1001/archneurol.2010.230
DO - 10.1001/archneurol.2010.230
M3 - Article
C2 - 20937951
AN - SCOPUS:77957961597
SN - 0003-9942
VL - 67
SP - 1231
EP - 1237
JO - Archives of neurology
JF - Archives of neurology
IS - 10
ER -