Abstract
Transcranial direct-current stimulation (tDCS) and repetitive transcranial magnetic stimulation (rTMS) are non-invasive brain stimulation (NIBS) modalities with therapeutic promise in childhood neuropsychiatric disorders. Although data are limited, prior studies have examined potential therapeutic utility in childhood mood disorders, attention-deficit hyperactivity disorder, autism, Tourette syndrome, and schizophrenia. Both techniques are thought to modulate the activity and excitability of disrupted neural networks. However, a refined knowledge of biological mechanisms could inform future clinical trials and practice. This is particularly critical for safety and optimizing the clinical potential of these treatments in youth. Prior mechanistic studies of NIBS include preclinical models, neurophysiology markers, neuroimaging, neurocognitive measures, and peripheral biomarkers. The majority of these investigations focused on adults with depression. This chapter will review the extant research on the biology of therapeutic tDCS and rTMS in depression. Much of this work focuses on adults but is considered in a developmental context with the aim of informing future research and clinical practice in youth.
| Original language | English (US) |
|---|---|
| Title of host publication | Pediatric Brain Stimulation: Mapping and Modulating The Developing Brain |
| Publisher | Elsevier Inc. |
| Pages | 305-320 |
| Number of pages | 16 |
| ISBN (Electronic) | 9780128020388 |
| ISBN (Print) | 9780128020012 |
| DOIs | |
| State | Published - May 17 2016 |
Fingerprint
Keywords
- Cortical excitability
- GABA
- Glutamate
- Neuroplasticity
- Non-invasive brain stimulation
- RTMS
- TDCS
- TMS
ASJC Scopus subject areas
- Neuroscience(all)
Cite this
Brain Stimulation in Pediatric Depression : Biological Mechanisms. / Croarkin, Paul E; Ameis, S. H.; MacMaster, F. P.
Pediatric Brain Stimulation: Mapping and Modulating The Developing Brain. Elsevier Inc., 2016. p. 305-320.Research output: Chapter in Book/Report/Conference proceeding › Chapter
}
TY - CHAP
T1 - Brain Stimulation in Pediatric Depression
T2 - Biological Mechanisms.
AU - Croarkin, Paul E
AU - Ameis, S. H.
AU - MacMaster, F. P.
PY - 2016/5/17
Y1 - 2016/5/17
N2 - Transcranial direct-current stimulation (tDCS) and repetitive transcranial magnetic stimulation (rTMS) are non-invasive brain stimulation (NIBS) modalities with therapeutic promise in childhood neuropsychiatric disorders. Although data are limited, prior studies have examined potential therapeutic utility in childhood mood disorders, attention-deficit hyperactivity disorder, autism, Tourette syndrome, and schizophrenia. Both techniques are thought to modulate the activity and excitability of disrupted neural networks. However, a refined knowledge of biological mechanisms could inform future clinical trials and practice. This is particularly critical for safety and optimizing the clinical potential of these treatments in youth. Prior mechanistic studies of NIBS include preclinical models, neurophysiology markers, neuroimaging, neurocognitive measures, and peripheral biomarkers. The majority of these investigations focused on adults with depression. This chapter will review the extant research on the biology of therapeutic tDCS and rTMS in depression. Much of this work focuses on adults but is considered in a developmental context with the aim of informing future research and clinical practice in youth.
AB - Transcranial direct-current stimulation (tDCS) and repetitive transcranial magnetic stimulation (rTMS) are non-invasive brain stimulation (NIBS) modalities with therapeutic promise in childhood neuropsychiatric disorders. Although data are limited, prior studies have examined potential therapeutic utility in childhood mood disorders, attention-deficit hyperactivity disorder, autism, Tourette syndrome, and schizophrenia. Both techniques are thought to modulate the activity and excitability of disrupted neural networks. However, a refined knowledge of biological mechanisms could inform future clinical trials and practice. This is particularly critical for safety and optimizing the clinical potential of these treatments in youth. Prior mechanistic studies of NIBS include preclinical models, neurophysiology markers, neuroimaging, neurocognitive measures, and peripheral biomarkers. The majority of these investigations focused on adults with depression. This chapter will review the extant research on the biology of therapeutic tDCS and rTMS in depression. Much of this work focuses on adults but is considered in a developmental context with the aim of informing future research and clinical practice in youth.
KW - Cortical excitability
KW - GABA
KW - Glutamate
KW - Neuroplasticity
KW - Non-invasive brain stimulation
KW - RTMS
KW - TDCS
KW - TMS
UR - http://www.scopus.com/inward/record.url?scp=85011791457&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85011791457&partnerID=8YFLogxK
U2 - 10.1016/B978-0-12-802001-2.00015-1
DO - 10.1016/B978-0-12-802001-2.00015-1
M3 - Chapter
AN - SCOPUS:85011791457
SN - 9780128020012
SP - 305
EP - 320
BT - Pediatric Brain Stimulation: Mapping and Modulating The Developing Brain
PB - Elsevier Inc.
ER -