Brain metastasis of crystal-deficient, CD68-positive alveolar soft part sarcoma: Ultrastructural features and differential diagnosis

Matthew D. Cykowski, John Hicks, David I. Sandberg, Adriana Olar, Julia A. Bridge, Patricia T. Greipp, Patricia Navarro, Steven Kolodziej, Meenakshi B. Bhattacharjee

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

We report a case of alveolar soft part sarcoma (ASPS) presenting as an isolated frontal lobe metastasis. The tumor demonstrated little or no immunoreactivity for a broad panel of antibodies yet strong, diffuse immunoreactivity with CD68. On electron microscopy, the characteristic rectangular to rhomboid crystalline inclusions of ASPS were not present. Electron-dense granules resembling peroxisomes were present, sometimes in association with elongated granular structures having a periodic, lattice-like arrangement. Metastatic ASPS was confirmed by demonstration of an ASPSCR1-TFE3 fusion and imaging studies that excluded metastatic Xp11.2 translocation renal cell carcinoma. The primary site was subsequently identified in the lower extremity.

Original languageEnglish (US)
Pages (from-to)69-77
Number of pages9
JournalUltrastructural Pathology
Volume39
Issue number1
DOIs
StatePublished - Feb 1 2015

Keywords

  • Alveolar soft part sarcoma
  • Brain metastasis
  • CD68

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Structural Biology

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    Cykowski, M. D., Hicks, J., Sandberg, D. I., Olar, A., Bridge, J. A., Greipp, P. T., Navarro, P., Kolodziej, S., & Bhattacharjee, M. B. (2015). Brain metastasis of crystal-deficient, CD68-positive alveolar soft part sarcoma: Ultrastructural features and differential diagnosis. Ultrastructural Pathology, 39(1), 69-77. https://doi.org/10.3109/01913123.2014.950778