Brain metabolism as measured with positron emission tomography

Serial assessment in a patient with familial Alzheimer's disease

N. R. Cutler, J. V. Haxby, R. Duara, C. L. Grady, A. M. Moore, Joseph E Parisi, J. White, L. Heston, R. M. Margolin, S. I. Rapoport

Research output: Contribution to journalArticle

51 Citations (Scopus)

Abstract

This paper presents, for the first time, repeated assessments of cerebral metabolism and neuropsychological competence in early Alzheimer's disease. Regional cerebral metabolic rates for glucose were measured with positron emission tomography and 18F-fluoro-2-deoxy-D-glucose on three occasions at 8-month intervals, in a 57-year-old man with Alzheimer's disease of 2 1/2 years' duration and with a family history of neuropathologically confirmed Alzheimer's disease. Data were compared with mean cerebral metabolic rates from 12 healthy men. No differences in regional cerebral metabolic rates for glucose were found on the initial patient scan, whereas metabolism on the second and third scans was reduced significantly in the parietal lobes and bilaterally in some parietal lobe regions. Memory loss was demonstrable at the first scan, but then and at later scans, other aspects of cognitive performance remained within normal limits (Wechsler Adult Intelligence Scale, Boston Naming Test, Two-dimensional Block Construction). The results show that memory loss can precede a measurable reduction of cerebral metabolism in early Alzheimer's disease, but that later reductions in parietal lobe metabolism may not be accompanied by additional measurable neuropsychological deficits.

Original languageEnglish (US)
Pages (from-to)1556-1561
Number of pages6
JournalNeurology
Volume35
Issue number11
StatePublished - 1985
Externally publishedYes

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Parietal Lobe
Positron-Emission Tomography
Alzheimer Disease
Memory Disorders
Brain
Glucose
Deoxyglucose
Intelligence
Mental Competency

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Cutler, N. R., Haxby, J. V., Duara, R., Grady, C. L., Moore, A. M., Parisi, J. E., ... Rapoport, S. I. (1985). Brain metabolism as measured with positron emission tomography: Serial assessment in a patient with familial Alzheimer's disease. Neurology, 35(11), 1556-1561.

Brain metabolism as measured with positron emission tomography : Serial assessment in a patient with familial Alzheimer's disease. / Cutler, N. R.; Haxby, J. V.; Duara, R.; Grady, C. L.; Moore, A. M.; Parisi, Joseph E; White, J.; Heston, L.; Margolin, R. M.; Rapoport, S. I.

In: Neurology, Vol. 35, No. 11, 1985, p. 1556-1561.

Research output: Contribution to journalArticle

Cutler, NR, Haxby, JV, Duara, R, Grady, CL, Moore, AM, Parisi, JE, White, J, Heston, L, Margolin, RM & Rapoport, SI 1985, 'Brain metabolism as measured with positron emission tomography: Serial assessment in a patient with familial Alzheimer's disease', Neurology, vol. 35, no. 11, pp. 1556-1561.
Cutler NR, Haxby JV, Duara R, Grady CL, Moore AM, Parisi JE et al. Brain metabolism as measured with positron emission tomography: Serial assessment in a patient with familial Alzheimer's disease. Neurology. 1985;35(11):1556-1561.
Cutler, N. R. ; Haxby, J. V. ; Duara, R. ; Grady, C. L. ; Moore, A. M. ; Parisi, Joseph E ; White, J. ; Heston, L. ; Margolin, R. M. ; Rapoport, S. I. / Brain metabolism as measured with positron emission tomography : Serial assessment in a patient with familial Alzheimer's disease. In: Neurology. 1985 ; Vol. 35, No. 11. pp. 1556-1561.
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