Brain-gut axis: From basic understanding to treatment of IBS and related disorders

Michael Camilleri, Carlo Di Lorenzo

Research output: Contribution to journalReview articlepeer-review

43 Scopus citations

Abstract

The present review describes advances in understanding the mechanisms and provide an update of present and promising therapy directed at the gut or the brain in the treatment of irritable bowel syndrome (IBS). The diagnosis of IBS typically is based on identification of symptoms, such as the Rome III criteria for IBS in adults and children. The criteria are similar in children and adults. The focus of the present review is the bowel dysfunction associated with IBS.

Original languageEnglish (US)
Pages (from-to)446-453
Number of pages8
JournalJournal of pediatric gastroenterology and nutrition
Volume54
Issue number4
DOIs
StatePublished - Apr 2012

Keywords

  • immune function
  • irritable bowel syndrome
  • motility
  • pain
  • secretion
  • sensation

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Gastroenterology

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