Brain biochemistry in autopsied patients with essential tremor

Holly A. Shill, Charles Howard Adler, Thomas G. Beach, Lih Fen Lue, John Nathaniel Caviness, Marwan N. Sabbagh, Lucia I. Sue, Douglas G. Walker

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

The pathology of essential tremor is increasingly being studied; however, there are limited studies of biochemical changes in this condition. We studied several candidate biochemical/anatomical systems in the brain stem, striatum, and cerebellum of 23 essential tremor subjects who came to autopsy, comparing them with a control population. Striatal tyrosine hydroxylase, a marker of dopaminergic neurons, was 91.7 ± 113.2 versus 96.4 ± 102.7 ng/mg (not significant) in cases and controls, respectively. Locus coeruleus dopamine beta-hydroxylase, a marker of noradrenergic neurons, was not significantly different between the essential tremor and control groups. Parvalbumin, a marker of GABAergic neurons, was 199.3 ± 42.0 versus 251.4 ± 74.8 ng/mg (P = .025) in the pons in the region of the locus coeruleus of essential tremor subjects versus controls, whereas there was no difference in cerebellar parvalbumin. These results are supportive of a possible role for reduced GABAergic function in the locus coeruleus in essential tremor. The hypothesis that essential tremor represents early Parkinson's disease was not supported, as striatal dopaminergic markers were not reduced compared with control subjects.

Original languageEnglish (US)
Pages (from-to)113-117
Number of pages5
JournalMovement Disorders
Volume27
Issue number1
DOIs
StatePublished - Jan 2012

Fingerprint

Essential Tremor
Biochemistry
Locus Coeruleus
Brain
Corpus Striatum
Parvalbumins
Adrenergic Neurons
GABAergic Neurons
Dopamine beta-Hydroxylase
Pons
Dopaminergic Neurons
Tyrosine 3-Monooxygenase
Cerebellum
Brain Stem
Parkinson Disease
Autopsy
Pathology
Control Groups
Population

Keywords

  • GABA
  • Norepinephrine
  • Pathology
  • Tremor

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology

Cite this

Shill, H. A., Adler, C. H., Beach, T. G., Lue, L. F., Caviness, J. N., Sabbagh, M. N., ... Walker, D. G. (2012). Brain biochemistry in autopsied patients with essential tremor. Movement Disorders, 27(1), 113-117. https://doi.org/10.1002/mds.24004

Brain biochemistry in autopsied patients with essential tremor. / Shill, Holly A.; Adler, Charles Howard; Beach, Thomas G.; Lue, Lih Fen; Caviness, John Nathaniel; Sabbagh, Marwan N.; Sue, Lucia I.; Walker, Douglas G.

In: Movement Disorders, Vol. 27, No. 1, 01.2012, p. 113-117.

Research output: Contribution to journalArticle

Shill, HA, Adler, CH, Beach, TG, Lue, LF, Caviness, JN, Sabbagh, MN, Sue, LI & Walker, DG 2012, 'Brain biochemistry in autopsied patients with essential tremor', Movement Disorders, vol. 27, no. 1, pp. 113-117. https://doi.org/10.1002/mds.24004
Shill, Holly A. ; Adler, Charles Howard ; Beach, Thomas G. ; Lue, Lih Fen ; Caviness, John Nathaniel ; Sabbagh, Marwan N. ; Sue, Lucia I. ; Walker, Douglas G. / Brain biochemistry in autopsied patients with essential tremor. In: Movement Disorders. 2012 ; Vol. 27, No. 1. pp. 113-117.
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