BRAF V600E Expression in Primary Melanoma and Its Association With Death: A Population-Based, Retrospective, Cross-Sectional Study

Jamison A. Harvey; Julia S. Lehman; Christine M. Lohse; Alanna M. Chamberlain; Svetomir N. Markovic; Celine M. Vachon; Jerry D. Brewer

doi:10.12788/cutis.0515

BRAF V600E Expression in Primary Melanoma and Its Association With Death: A Population-Based, Retrospective, Cross-Sectional Study

Jamison A. Harvey, Julia S. Lehman, Christine M. Lohse, Alanna M. Chamberlain, Svetomir N. Markovic, Celine M. Vachon, Jerry D. Brewer

Research output: Contribution to journal › Article › peer-review

Abstract

Approximately 50% of melanomas contain BRAF mutations; the effects on survival are unclear. We aimed to determine whether mutant BRAF expression in melanoma differs according to age, sex, and melanoma-specific survival. A total of 638 patients who resided in Olmsted County, Minnesota, with a first lifetime diagnosis of melanoma between 1970 and 2009 were identified from the Rochester Epidemiology Project (REP). Available tissue was analyzed for a BRAF V600E mutation with immunohistochemistry.

Original language	English (US)
Journal	Cutis
Volume	109
Issue number	5
DOIs	https://doi.org/10.12788/cutis.0515
State	Published - May 2022

ASJC Scopus subject areas

General Medicine

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title = "BRAF V600E Expression in Primary Melanoma and Its Association With Death: A Population-Based, Retrospective, Cross-Sectional Study",

abstract = "Approximately 50% of melanomas contain BRAF mutations; the effects on survival are unclear. We aimed to determine whether mutant BRAF expression in melanoma differs according to age, sex, and melanoma-specific survival. A total of 638 patients who resided in Olmsted County, Minnesota, with a first lifetime diagnosis of melanoma between 1970 and 2009 were identified from the Rochester Epidemiology Project (REP). Available tissue was analyzed for a BRAF V600E mutation with immunohistochemistry.",

author = "Harvey, {Jamison A.} and Lehman, {Julia S.} and Lohse, {Christine M.} and Chamberlain, {Alanna M.} and Markovic, {Svetomir N.} and Vachon, {Celine M.} and Brewer, {Jerry D.}",

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AU - Chamberlain, Alanna M.

AU - Markovic, Svetomir N.

AU - Vachon, Celine M.

AU - Brewer, Jerry D.

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AB - Approximately 50% of melanomas contain BRAF mutations; the effects on survival are unclear. We aimed to determine whether mutant BRAF expression in melanoma differs according to age, sex, and melanoma-specific survival. A total of 638 patients who resided in Olmsted County, Minnesota, with a first lifetime diagnosis of melanoma between 1970 and 2009 were identified from the Rochester Epidemiology Project (REP). Available tissue was analyzed for a BRAF V600E mutation with immunohistochemistry.

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BRAF V600E Expression in Primary Melanoma and Its Association With Death: A Population-Based, Retrospective, Cross-Sectional Study

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