BRAF mutation is not predictive of long-term outcome in papillary thyroid carcinoma

Lauren E. Henke, John D. Pfeifer, Changquing Ma, Stephanie M. Perkins, Todd Dewees, Samir El-Mofty, Jeffrey F. Moley, Brian Nussenbaum, Bruce H. Haughey, Thomas J. Baranski, Julie K. Schwarz, Perry W. Grigsby

Research output: Contribution to journalArticlepeer-review

41 Scopus citations

Abstract

The BRAF mutation occurs commonly in papillary thyroid carcinoma (PTC). Previous investigations of its utility to predict recurrence-free survival (RFS) and disease-specific survival (DSS) have reported conflicting results and its role remains unclear. The purpose of this retrospective study was to determine the incidence of the BRAF mutation and analyze its relationship to clinicopathologic risk factors and long-term outcomes in the largest, single-institution American cohort to date. BRAF mutational status was determined in 508 PTC patients using RFLP analysis. The relationships between BRAF mutation status, patient and tumor characteristics, RFS, and DSS were analyzed. The BRAF mutation was present in 67% of patients. On multivariate analysis, presence of the mutation predicted only for capsular invasion (HR, 1.7; 95% CI, 1.1-2.6), cervical lymph node involvement (HR, 1.7; 95% CI, 1.1-2.7), and classic papillary histology (HR, 1.8; 95% CI 1.1-2.9). There was no significant relationship between the BRAF mutation and RFS or DSS, an observation that was consistent across univariate, multivariate, and Kaplan-Meier analyses. This is the most extensive study to date in the United States to demonstrate that BRAF mutation is of no predictive value for recurrence or survival in PTC. We found correlations of BRAF status and several clinicopathologic characteristics of high-risk disease, but limited evidence that the mutation correlates with more extensive or aggressive disease. This analysis suggests that BRAF is minimally prognostic in PTC. However, prevalence of the BRAF mutation is 70% in the general population, providing the opportunity for targeted therapy.

Original languageEnglish (US)
Pages (from-to)791-799
Number of pages9
JournalCancer medicine
Volume4
Issue number6
DOIs
StatePublished - Jun 1 2015

Keywords

  • BRAF V600
  • BRAF mutation
  • BRAF mutation survival
  • Papillary thyroid carcinoma
  • Thyroidectomy

ASJC Scopus subject areas

  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Cancer Research

Fingerprint Dive into the research topics of 'BRAF mutation is not predictive of long-term outcome in papillary thyroid carcinoma'. Together they form a unique fingerprint.

Cite this