Brachial-ankle pulse wave velocity is associated with walking distance in patients referred for peripheral arterial disease evaluation

Comfort A. Amoh-Tonto, A. Rauoof Malik, Venkateswarlu Kondragunta, Zeenat Ali, Iftikhar J. Kullo

Research output: Contribution to journalArticlepeer-review

30 Scopus citations

Abstract

Objective: Impaired functional capacity predicts morbidity and increased mortality in patients with PAD. We hypothesized that brachial-ankle pulse wave velocity (baPWV), a measure of arterial stiffness, is associated with functional capacity in patients undergoing noninvasive evaluation for peripheral arterial disease (PAD). Methods: We studied 114 patients (age 68 ± 10 years) referred to Mayo Clinic's noninvasive vascular laboratory. Functional capacity was estimated in terms of distance walked in 5 min on a treadmill at a speed of 1.0-2.0 mph. Ankle-brachial index (ABI) was obtained with Doppler method before and 1 min after exercise. baPWV was estimated noninvasively using an oscillometric device. The association of baPWV with walking distance was assessed using accelerated failure time and Cox proportional-hazards models. Results: The mean baPWV was higher in patients who were unable to complete the walk test compared to those who successfully completed the test (P = 0.008). Higher baPWV was associated with a lower walking distance after adjustment for heart rate, mean arterial pressure, and cardiovascular risk factors (P = 0.017) and after additional adjustment for pulse pressure (P = 0.034) and ABI (P = 0.030). Higher baPWV was associated with failure to complete the treadmill walk test, after adjustment for heart rate, mean arterial pressure, and cardiovascular risk factors (P = 0.025) and after additional adjustment for pulse pressure (P = 0.041) and ABI (P = 0.039). Conclusion: Increased baPWV, a measure of arterial stiffness, is associated with impaired functional capacity in patients undergoing evaluation for PAD.

Original languageEnglish (US)
Pages (from-to)173-178
Number of pages6
JournalAtherosclerosis
Volume206
Issue number1
DOIs
StatePublished - Sep 2009

Keywords

  • Arterial stiffness
  • Brachial-ankle pulse wave velocity
  • Functional capacity
  • Peripheral arterial disease

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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