Bowel ultrasonography in the management of Crohn's disease. A review with recommendations of an international panel of experts

Emma Calabrese, Christian Maaser, Francesca Zorzi, Klaus Kannengiesser, Stephen B. Hanauer, David H. Bruining, Marietta Iacucci, Giovanni Maconi, Kerri L. Novak, Remo Panaccione, Deike Strobel, Stephanie R. Wilson, Mamoru Watanabe, Francesco Pallone, Subrata Ghosh

Research output: Contribution to journalArticle

41 Citations (Scopus)

Abstract

Background: Bowel ultrasonography (US) is considered a useful technique for assessing mural inflammation and complications in Crohn's disease (CD). The aim of this review is to appraise the evidence on the accuracy of bowel US for CD. In addition, we aim to provide recommendations for its optimal use. Methods: Publications were identified by literature search from 1992 to 2014 and selected based on predefined criteria: 15 or more patients; bowel US for diagnosing CD, complications, postoperative recurrence, activity; adequate reference standards; prospective study design; data reported to allow calculation of sensitivity, specificity, agreement, or correlation values; articles published in English. Results: The search yielded 655 articles, of which 63 were found to be eligible and retrieved as full-text articles for analysis. Bowel US showed 79.7% sensitivity and 96.7% specificity for the diagnosis of suspected CD, and 89% sensitivity and 94.3% specificity for initial assessment in established patients with CD. Bowel US identified ileal CD with 92.7% sensitivity, 88.2% specificity, and colon CD with 81.8% sensitivity, 95.3% specificity, with lower accuracy for detecting proximal lesions. The oral contrast agent improves the sensitivity and specificity in determining CD lesions and in assessing sites and extent. Conclusions: Bowel US is a tool for evaluation of CD lesions in terms of complications, postoperative recurrence, and monitoring response to medical therapy; it reliably detects postoperative recurrence and complications, as well as offers the possibility of monitoring disease progression.

Original languageEnglish (US)
Pages (from-to)1168-1183
Number of pages16
JournalInflammatory Bowel Diseases
Volume22
Issue number5
DOIs
StatePublished - May 1 2016

Fingerprint

Crohn Disease
Ultrasonography
Sensitivity and Specificity
Recurrence
Ileal Diseases
Contrast Media
Disease Progression
Publications
Colon
Prospective Studies
Inflammation

Keywords

  • contrast-enhanced ultrasound
  • cross-sectional imaging technique
  • detection
  • inflammation
  • inflammatory bowel disease
  • small intestine contrast ultrasonography
  • ultrasound

ASJC Scopus subject areas

  • Gastroenterology
  • Immunology and Allergy

Cite this

Calabrese, E., Maaser, C., Zorzi, F., Kannengiesser, K., Hanauer, S. B., Bruining, D. H., ... Ghosh, S. (2016). Bowel ultrasonography in the management of Crohn's disease. A review with recommendations of an international panel of experts. Inflammatory Bowel Diseases, 22(5), 1168-1183. https://doi.org/10.1097/MIB.0000000000000706

Bowel ultrasonography in the management of Crohn's disease. A review with recommendations of an international panel of experts. / Calabrese, Emma; Maaser, Christian; Zorzi, Francesca; Kannengiesser, Klaus; Hanauer, Stephen B.; Bruining, David H.; Iacucci, Marietta; Maconi, Giovanni; Novak, Kerri L.; Panaccione, Remo; Strobel, Deike; Wilson, Stephanie R.; Watanabe, Mamoru; Pallone, Francesco; Ghosh, Subrata.

In: Inflammatory Bowel Diseases, Vol. 22, No. 5, 01.05.2016, p. 1168-1183.

Research output: Contribution to journalArticle

Calabrese, E, Maaser, C, Zorzi, F, Kannengiesser, K, Hanauer, SB, Bruining, DH, Iacucci, M, Maconi, G, Novak, KL, Panaccione, R, Strobel, D, Wilson, SR, Watanabe, M, Pallone, F & Ghosh, S 2016, 'Bowel ultrasonography in the management of Crohn's disease. A review with recommendations of an international panel of experts', Inflammatory Bowel Diseases, vol. 22, no. 5, pp. 1168-1183. https://doi.org/10.1097/MIB.0000000000000706
Calabrese, Emma ; Maaser, Christian ; Zorzi, Francesca ; Kannengiesser, Klaus ; Hanauer, Stephen B. ; Bruining, David H. ; Iacucci, Marietta ; Maconi, Giovanni ; Novak, Kerri L. ; Panaccione, Remo ; Strobel, Deike ; Wilson, Stephanie R. ; Watanabe, Mamoru ; Pallone, Francesco ; Ghosh, Subrata. / Bowel ultrasonography in the management of Crohn's disease. A review with recommendations of an international panel of experts. In: Inflammatory Bowel Diseases. 2016 ; Vol. 22, No. 5. pp. 1168-1183.
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abstract = "Background: Bowel ultrasonography (US) is considered a useful technique for assessing mural inflammation and complications in Crohn's disease (CD). The aim of this review is to appraise the evidence on the accuracy of bowel US for CD. In addition, we aim to provide recommendations for its optimal use. Methods: Publications were identified by literature search from 1992 to 2014 and selected based on predefined criteria: 15 or more patients; bowel US for diagnosing CD, complications, postoperative recurrence, activity; adequate reference standards; prospective study design; data reported to allow calculation of sensitivity, specificity, agreement, or correlation values; articles published in English. Results: The search yielded 655 articles, of which 63 were found to be eligible and retrieved as full-text articles for analysis. Bowel US showed 79.7{\%} sensitivity and 96.7{\%} specificity for the diagnosis of suspected CD, and 89{\%} sensitivity and 94.3{\%} specificity for initial assessment in established patients with CD. Bowel US identified ileal CD with 92.7{\%} sensitivity, 88.2{\%} specificity, and colon CD with 81.8{\%} sensitivity, 95.3{\%} specificity, with lower accuracy for detecting proximal lesions. The oral contrast agent improves the sensitivity and specificity in determining CD lesions and in assessing sites and extent. Conclusions: Bowel US is a tool for evaluation of CD lesions in terms of complications, postoperative recurrence, and monitoring response to medical therapy; it reliably detects postoperative recurrence and complications, as well as offers the possibility of monitoring disease progression.",
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AU - Hanauer, Stephen B.

AU - Bruining, David H.

AU - Iacucci, Marietta

AU - Maconi, Giovanni

AU - Novak, Kerri L.

AU - Panaccione, Remo

AU - Strobel, Deike

AU - Wilson, Stephanie R.

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