Abstract
Introduction: To evaluate the safety and efficacy of incobotulinumtoxinA (IncoA) injection for treatment of essential hand tremor. In essential tremor and Parkinson's disease tremor, administration of onabotulinumtoxinA via a fixed injection approach improves the tremor but a high percentage of patients (30–70%) develop moderate to severe hand weakness which has limited its use in clinical practice. Methods: This study was performed from July 2013 to July 2016 on 33 subjects. This is a double-blind, placebo-controlled, crossover trial injecting 80–120 units of IncoA into 8–14 hand and forearm muscles using a customized approach. The subjects were followed for 28 weeks. The treatment efficacy was evaluated by the Fahn Tolosa Marin tremor rating score and NIH genetic criteria for tremor severity at 4 and 8 weeks after each of the two sets of treatments. Hand strength was assessed by an ergometer. Results: There was statistically significant improvement in clinical rating score of tremor at 4 and 8 weeks following the IncoA injection. Conclusion: In this study, injection of IncoA treatment via a customized approach improved essential tremor on the clinical scales and patient's perception with a low occurrence of significant hand weakness.
Original language | English (US) |
---|---|
Pages (from-to) | 65-69 |
Number of pages | 5 |
Journal | Parkinsonism and Related Disorders |
Volume | 56 |
DOIs | |
State | Published - Nov 1 2018 |
Keywords
- Botulinum toxin
- Clinical trial
- Essential tremor
- IncobotulinumtoxinA
ASJC Scopus subject areas
- Neurology
- Geriatrics and Gerontology
- Clinical Neurology