Both early and late cognitive dysfunction affects the electroencephalogram in Parkinson's disease

J. N. Caviness; J. G. Hentz; V. G. Evidente; E. Driver-Dunckley; J. Samanta; P. Mahant; D. J. Connor; M. N. Sabbagh; H. A. Shill; C. H. Adler

doi:10.1016/j.parkreldis.2007.01.003

Both early and late cognitive dysfunction affects the electroencephalogram in Parkinson's disease

J. N. Caviness, J. G. Hentz, V. G. Evidente, E. Driver-Dunckley, J. Samanta, P. Mahant, D. J. Connor, M. N. Sabbagh, H. A. Shill, C. H. Adler

Neurology

Research output: Contribution to journal › Article › peer-review

81 Scopus citations

Abstract

We sought to define quantitative electroencephalographic (EEG) measures as biomarkers of both early and late cognitive decline in Parkinson's disease (PD). PD subjects classified as cognitively normal (PD-CogNL), mild cognitive impairment (PD-MCI), and dementia (PD-D) were studied. Cognitive status and neuropsychological testing was correlated with background rhythm and frequency band EEG power across five frequency bands. We conclude that global EEG measures have potential use as biomarkers in the study of both early and late cognitive deterioration in PD, including for evaluating its treatment. PD-MCI has mean quantitative EEG characteristics that represent an intermediate electrophysiological state between PD-CogNL and PD-D.

Original language	English (US)
Pages (from-to)	348-354
Number of pages	7
Journal	Parkinsonism and Related Disorders
Volume	13
Issue number	6
DOIs	https://doi.org/10.1016/j.parkreldis.2007.01.003
State	Published - Aug 2007

Keywords

Dementia
EEG
Mild cognitive impairment
Parkinson's disease

ASJC Scopus subject areas

Neurology
Geriatrics and Gerontology
Clinical Neurology

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10.1016/j.parkreldis.2007.01.003

Cite this

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title = "Both early and late cognitive dysfunction affects the electroencephalogram in Parkinson's disease",

abstract = "We sought to define quantitative electroencephalographic (EEG) measures as biomarkers of both early and late cognitive decline in Parkinson's disease (PD). PD subjects classified as cognitively normal (PD-CogNL), mild cognitive impairment (PD-MCI), and dementia (PD-D) were studied. Cognitive status and neuropsychological testing was correlated with background rhythm and frequency band EEG power across five frequency bands. We conclude that global EEG measures have potential use as biomarkers in the study of both early and late cognitive deterioration in PD, including for evaluating its treatment. PD-MCI has mean quantitative EEG characteristics that represent an intermediate electrophysiological state between PD-CogNL and PD-D.",

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AU - Caviness, J. N.

AU - Hentz, J. G.

AU - Evidente, V. G.

AU - Driver-Dunckley, E.

AU - Samanta, J.

AU - Mahant, P.

AU - Connor, D. J.

AU - Sabbagh, M. N.

AU - Shill, H. A.

AU - Adler, C. H.

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Both early and late cognitive dysfunction affects the electroencephalogram in Parkinson's disease

Abstract

Keywords

ASJC Scopus subject areas

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