Both early and late cognitive dysfunction affects the electroencephalogram in Parkinson's disease

J. N. Caviness, J. G. Hentz, V. G. Evidente, E. Driver-Dunckley, J. Samanta, P. Mahant, D. J. Connor, M. N. Sabbagh, H. A. Shill, C. H. Adler

Research output: Contribution to journalArticle

78 Scopus citations

Abstract

We sought to define quantitative electroencephalographic (EEG) measures as biomarkers of both early and late cognitive decline in Parkinson's disease (PD). PD subjects classified as cognitively normal (PD-CogNL), mild cognitive impairment (PD-MCI), and dementia (PD-D) were studied. Cognitive status and neuropsychological testing was correlated with background rhythm and frequency band EEG power across five frequency bands. We conclude that global EEG measures have potential use as biomarkers in the study of both early and late cognitive deterioration in PD, including for evaluating its treatment. PD-MCI has mean quantitative EEG characteristics that represent an intermediate electrophysiological state between PD-CogNL and PD-D.

Original languageEnglish (US)
Pages (from-to)348-354
Number of pages7
JournalParkinsonism and Related Disorders
Volume13
Issue number6
DOIs
StatePublished - Aug 1 2007

Keywords

  • Dementia
  • EEG
  • Mild cognitive impairment
  • Parkinson's disease

ASJC Scopus subject areas

  • Neurology
  • Geriatrics and Gerontology
  • Clinical Neurology

Fingerprint Dive into the research topics of 'Both early and late cognitive dysfunction affects the electroencephalogram in Parkinson's disease'. Together they form a unique fingerprint.

Cite this