Bosentan for pulmonary hypertension and other pulmonary diseases: Emerging evidence

Research output: Contribution to journalArticle

Abstract

Endothelin-1 is a potent vasoconstrictor and mitogen that is primarily synthesized and released from vascular endothelial cells. Bosentan is a dual endothelin-receptor antagonist that initially received approval for treatment of WHO group I pulmonary arterial hypertension (PAH) for patients in functional classes III and IV. Analysis of a study conducted in functional class II patients (Endothelin Antagonist Trial in Mildly Symptomatic PAH Patients (EARLY) trial) suggest its efficacy for these less symptomatic patients. In addition, bosentan has demonstrated efficacy in patients with congenital heart disease and Eisenmengers syndrome with right to left shunting and in HIV-related PAH. Studies of bosentan in inoperable or residual chronic thromboembolic pulmonary hypertension suggest possible efficacy. Bosentan appears promising in patients with idiopathic pulmonary fibrosis who do not have pulmonary hypertension. Combinations of bosentan with other PAH therapies such as iloprost and slidenafil may have incremental benefit over monotherapy.

Original languageEnglish (US)
Pages (from-to)459-468
Number of pages10
JournalFuture Cardiology
Volume4
Issue number5
DOIs
StatePublished - Sep 1 2008

Keywords

  • Bosentan
  • Endothelin
  • Endothelin-receptor antagonist
  • Pulmonary hypertension
  • Scleroderma

ASJC Scopus subject areas

  • Molecular Medicine
  • Cardiology and Cardiovascular Medicine

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