Bortezomib-induced acute interstitial nephritis

Wisit Cheungpasitporn; Nelson Leung; S. Vincent Rajkumar; Lynn D. Cornell; Sanjeev Sethi; Andrea Angioi; Fernando C. Fervenza

doi:10.1093/ndt/gfv222

Bortezomib-induced acute interstitial nephritis

Wisit Cheungpasitporn, Nelson Leung, S. Vincent Rajkumar, Lynn D. Cornell, Sanjeev Sethi, Andrea Angioi, Fernando C. Fervenza

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Abstract

Acute interstitial nephritis (AIN) is one of the important causes of acute kidney injury (AKI) resulting from inflammatory tubulointerstitial injury induced by medications, infections and systemic diseases. Bortezomib has been increasingly used especially in renal related indications such as multiple myeloma and monoclonal gammopathy of renal significance. Severe allergic reactions from bortezomib treatment including AIN have not been described in the literature. We report a 47-year-old white man who developed biopsy-proven allergic AIN after treatment with bortezomib for his C3 glomerulonephritis. The patient's kidney function improved after treatment with glucocorticoid therapy and discontinuation of bortezomib, but worsened with recurrent AKI episode after re-initiation of bortezomib. His renal function improved after glucocorticoid therapy and discontinuation of bortezomib. To our knowledge, this is the first report of a biopsy-proven AIN from bortezomib.

Original language	English (US)
Pages (from-to)	1225-1229
Number of pages	5
Journal	Nephrology Dialysis Transplantation
Volume	30
Issue number	7
DOIs	https://doi.org/10.1093/ndt/gfv222
State	Published - Jul 1 2015

Keywords

C3 glomerulonephritis
acute interstitial nephritis
bortezomib
monoclonal gammopathy
nephrotoxicity

ASJC Scopus subject areas

Nephrology
Transplantation

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title = "Bortezomib-induced acute interstitial nephritis",

abstract = "Acute interstitial nephritis (AIN) is one of the important causes of acute kidney injury (AKI) resulting from inflammatory tubulointerstitial injury induced by medications, infections and systemic diseases. Bortezomib has been increasingly used especially in renal related indications such as multiple myeloma and monoclonal gammopathy of renal significance. Severe allergic reactions from bortezomib treatment including AIN have not been described in the literature. We report a 47-year-old white man who developed biopsy-proven allergic AIN after treatment with bortezomib for his C3 glomerulonephritis. The patient's kidney function improved after treatment with glucocorticoid therapy and discontinuation of bortezomib, but worsened with recurrent AKI episode after re-initiation of bortezomib. His renal function improved after glucocorticoid therapy and discontinuation of bortezomib. To our knowledge, this is the first report of a biopsy-proven AIN from bortezomib.",

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AU - Leung, Nelson

AU - Rajkumar, S. Vincent

AU - Cornell, Lynn D.

AU - Sethi, Sanjeev

AU - Angioi, Andrea

AU - Fervenza, Fernando C.

PY - 2015/7/1

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N2 - Acute interstitial nephritis (AIN) is one of the important causes of acute kidney injury (AKI) resulting from inflammatory tubulointerstitial injury induced by medications, infections and systemic diseases. Bortezomib has been increasingly used especially in renal related indications such as multiple myeloma and monoclonal gammopathy of renal significance. Severe allergic reactions from bortezomib treatment including AIN have not been described in the literature. We report a 47-year-old white man who developed biopsy-proven allergic AIN after treatment with bortezomib for his C3 glomerulonephritis. The patient's kidney function improved after treatment with glucocorticoid therapy and discontinuation of bortezomib, but worsened with recurrent AKI episode after re-initiation of bortezomib. His renal function improved after glucocorticoid therapy and discontinuation of bortezomib. To our knowledge, this is the first report of a biopsy-proven AIN from bortezomib.

AB - Acute interstitial nephritis (AIN) is one of the important causes of acute kidney injury (AKI) resulting from inflammatory tubulointerstitial injury induced by medications, infections and systemic diseases. Bortezomib has been increasingly used especially in renal related indications such as multiple myeloma and monoclonal gammopathy of renal significance. Severe allergic reactions from bortezomib treatment including AIN have not been described in the literature. We report a 47-year-old white man who developed biopsy-proven allergic AIN after treatment with bortezomib for his C3 glomerulonephritis. The patient's kidney function improved after treatment with glucocorticoid therapy and discontinuation of bortezomib, but worsened with recurrent AKI episode after re-initiation of bortezomib. His renal function improved after glucocorticoid therapy and discontinuation of bortezomib. To our knowledge, this is the first report of a biopsy-proven AIN from bortezomib.

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Bortezomib-induced acute interstitial nephritis

Abstract

Keywords

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