Bortezomib-induced acute interstitial nephritis

Wisit Cheungpasitporn, Nelson Leung, S Vincent Rajkumar, Lynn D. Cornell, Sanjeev M Sethi, Andrea Angioi, Fernando Custodio Fervenza

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

Acute interstitial nephritis (AIN) is one of the important causes of acute kidney injury (AKI) resulting from inflammatory tubulointerstitial injury induced by medications, infections and systemic diseases. Bortezomib has been increasingly used especially in renal related indications such as multiple myeloma and monoclonal gammopathy of renal significance. Severe allergic reactions from bortezomib treatment including AIN have not been described in the literature. We report a 47-year-old white man who developed biopsy-proven allergic AIN after treatment with bortezomib for his C3 glomerulonephritis. The patient's kidney function improved after treatment with glucocorticoid therapy and discontinuation of bortezomib, but worsened with recurrent AKI episode after re-initiation of bortezomib. His renal function improved after glucocorticoid therapy and discontinuation of bortezomib. To our knowledge, this is the first report of a biopsy-proven AIN from bortezomib.

Original languageEnglish (US)
Pages (from-to)1225-1229
Number of pages5
JournalNephrology Dialysis Transplantation
Volume30
Issue number7
DOIs
StatePublished - Jul 1 2015

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Keywords

  • acute interstitial nephritis
  • bortezomib
  • C3 glomerulonephritis
  • monoclonal gammopathy
  • nephrotoxicity

ASJC Scopus subject areas

  • Nephrology
  • Transplantation

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