Bortezomib-induced acute interstitial nephritis

Wisit Cheungpasitporn; Nelson Leung; S Vincent Rajkumar; Lynn D. Cornell; Sanjeev M Sethi; Andrea Angioi; Fernando Custodio Fervenza

doi:10.1093/ndt/gfv222

Bortezomib-induced acute interstitial nephritis

Wisit Cheungpasitporn, Nelson Leung, S Vincent Rajkumar, Lynn D. Cornell, Sanjeev M Sethi, Andrea Angioi, Fernando Custodio Fervenza

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11 Scopus citations

Abstract

Acute interstitial nephritis (AIN) is one of the important causes of acute kidney injury (AKI) resulting from inflammatory tubulointerstitial injury induced by medications, infections and systemic diseases. Bortezomib has been increasingly used especially in renal related indications such as multiple myeloma and monoclonal gammopathy of renal significance. Severe allergic reactions from bortezomib treatment including AIN have not been described in the literature. We report a 47-year-old white man who developed biopsy-proven allergic AIN after treatment with bortezomib for his C3 glomerulonephritis. The patient's kidney function improved after treatment with glucocorticoid therapy and discontinuation of bortezomib, but worsened with recurrent AKI episode after re-initiation of bortezomib. His renal function improved after glucocorticoid therapy and discontinuation of bortezomib. To our knowledge, this is the first report of a biopsy-proven AIN from bortezomib.

Original language	English (US)
Pages (from-to)	1225-1229
Number of pages	5
Journal	Nephrology Dialysis Transplantation
Volume	30
Issue number	7
DOIs	https://doi.org/10.1093/ndt/gfv222
State	Published - Jul 1 2015

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Keywords

acute interstitial nephritis
bortezomib
C3 glomerulonephritis
monoclonal gammopathy
nephrotoxicity

ASJC Scopus subject areas

Nephrology
Transplantation

Cite this

Cheungpasitporn, W., Leung, N., Rajkumar, S. V., Cornell, L. D., Sethi, S. M., Angioi, A., & Fervenza, F. C. (2015). Bortezomib-induced acute interstitial nephritis. Nephrology Dialysis Transplantation, 30(7), 1225-1229. https://doi.org/10.1093/ndt/gfv222

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Access to Document

10.1093/ndt/gfv222