TY - JOUR
T1 - Bookmarking the genome
T2 - Maintenance of epigenetic information
AU - Zaidi, Sayyed K.
AU - Young, Daniel W.
AU - Montecino, Martin
AU - Van Wijnen, Andre J.
AU - Stein, Janet L.
AU - Lian, Jane B.
AU - Stein, Gary S.
PY - 2011/5/27
Y1 - 2011/5/27
N2 - Mitotic inheritance of gene function is obligatory to sustain biological control. Emerging evidence suggests that epigenetic mechanisms are linked to transmission of cell fate, lineage commitment, and maintenance of cellular phenotype in progeny cells. Mechanisms of epigenetic memory include gene silencing by DNA methylation, transcriptional regulation by histone modifications, regulation of gene expression by noncoding small RNA molecules, and retention of regulatory machinery on target gene loci for activation and repression. We will focus on the regulatory implications of epigenetic memory for physiological control and for the onset and progression of disease.
AB - Mitotic inheritance of gene function is obligatory to sustain biological control. Emerging evidence suggests that epigenetic mechanisms are linked to transmission of cell fate, lineage commitment, and maintenance of cellular phenotype in progeny cells. Mechanisms of epigenetic memory include gene silencing by DNA methylation, transcriptional regulation by histone modifications, regulation of gene expression by noncoding small RNA molecules, and retention of regulatory machinery on target gene loci for activation and repression. We will focus on the regulatory implications of epigenetic memory for physiological control and for the onset and progression of disease.
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U2 - 10.1074/jbc.R110.197061
DO - 10.1074/jbc.R110.197061
M3 - Short survey
C2 - 21454629
AN - SCOPUS:79956293082
SN - 0021-9258
VL - 286
SP - 18355
EP - 18361
JO - Journal of Biological Chemistry
JF - Journal of Biological Chemistry
IS - 21
ER -